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Dan Maarten Berger
Researcher at OSI Pharmaceuticals
Publications - 28
Citations - 756
Dan Maarten Berger is an academic researcher from OSI Pharmaceuticals. The author has contributed to research in topics: Kinase & Polycystic kidney disease. The author has an hindex of 14, co-authored 28 publications receiving 729 citations.
Papers
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Journal ArticleDOI
4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors.
Allan Wissner,Dan Maarten Berger,Diane H. Boschelli,M. B. Floyd,Lee M. Greenberger,Brian C. Gruber,Bernard Dean Johnson,Nellie Mamuya,Ramaswamy Nilakantan,Marvin F Reich,Ru Shen,Hwei-Ru Tsou,E. Upeslacis,Yu Feng Wang,Biqi Wu,Fei Ye,Zhang Nan +16 more
TL;DR: 4-anilinoquinoline-3-carbonitriles are effective inhibitors of EGF-R kinase with activity comparable to the 4-anILinoquinazoline-based inhibitors.
Patent
Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
Allan Wissner,Hwei-Ru Tsou,Dan Maarten Berger,Middleton Brawner Floyd,Hamann Philip Ross,Nan Zhang,Philip Frost +6 more
TL;DR: In this article, the authors provided compounds of formula (1) wherein R1, G 1, G 2, G2, R4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof, which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
Patent
3-cyanoquinolines,3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
Diane H. Boschelli,Wang Yanong,Frank Boschelli,Dan Maarten Berger,Nan Zhang,Dennis Powell,Fei Ye,Ayako Yamashita,Frenel Fils Demorin,Biqi Wu,Hwei-Ru Tsou,Elsebe Geraldine Overbeek-Klumpers,Allan Wissner +12 more
TL;DR: In this paper, the authors present a list of compounds of formula (I) having the structure or a pharmaceutically salt thereof that are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
Journal ArticleDOI
Novel multidrug resistance reversal agents.
Dan Maarten Berger,Ron Citarella,Minu Dutia,Lee M. Greenberger,Hallett William A,Rolf Paul,Dennis Powell +6 more
TL;DR: The reversal agents which consistently showed the highest activity, together with low toxicity, were alpha-aryl-alpha-thiotolylalkanenitrile tetrahydroisoquinoline derivatives with electron-rich alkoxy substituents on the aromatic rings.
Journal ArticleDOI
Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors
Dan Maarten Berger,Nancy Torres,Minu Dutia,Dennis Powell,Greg Ciszewski,Ariamala Gopalsamy,Jeremy I. Levin,Kyung-Hee Kim,Weixin Xu,James M. Wilhelm,Yongbo Hu,Karen Collins,Larry Feldberg,Steven C. Kim,Eileen Frommer,Donald Wojciechowicz,Robert Mallon +16 more
TL;DR: With basic amine residues appended to C-3 aryl residues, cellular activity and solubility were enhanced over previously described compounds of this class.