Ariamala Gopalsamy

TL;DR: The feasibility of developing small molecules that inhibit sFRP-1 and stimulate canonical Wnt signaling to increase bone formation is demonstrated and robust anabolic activity in an ex vivo organ culture assay is demonstrated.

TL;DR: Small-molecule benzisoxazole derivatives as Hsp90 inhibitors are identified and structure based optimization led to the identification of potent analogues, such as 13, with good biochemical profiles.

TL;DR: A novel series of p21 chemoselective agents containing a pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides were identified by high throughput screening and optimization of the amide region by parallel synthesis and the iterative design toward understanding structure-activity relationship to improve potency are described.

TL;DR: Through high throughput screening, substituted proline sulfonamide 6 was identified as HCV NS5b RNA-dependent RNA polymerase inhibitor and optimization of various regions of the lead molecule resulted in compounds that displayed good potency and selectivity.

TL;DR: The Doebner quinoline synthesis has been adopted to solid phase as discussed by the authors, and acylation of an amino acid coupled to the Rink polystyrene resin with pyruvyl chloride afforded the immobilized amide.