D
Daniel Guenard
Researcher at Institut de Chimie des Substances Naturelles
Publications - 139
Citations - 6687
Daniel Guenard is an academic researcher from Institut de Chimie des Substances Naturelles. The author has contributed to research in topics: Rhazinilam & Baccatin III. The author has an hindex of 39, co-authored 139 publications receiving 6511 citations. Previous affiliations of Daniel Guenard include Centre national de la recherche scientifique & L'Oréal.
Papers
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Journal ArticleDOI
Relationships between the structure of taxol analogues and their antimitotic activity.
Francoise Gueritte-Voegelein,Daniel Guenard,François Lavelle,M.-T. Le Goff,L. Mangatal,Pierre Jean-Paul Potier +5 more
TL;DR: This structure-activity relationship study shows that inhibition of microtubule disassembly is quite sensitive to the configuration at C-2' and C-3'.
Journal ArticleDOI
Highly efficient, practical approach to natural taxol
Jean Noel Denis,Andrew E. Greene,Daniel Guenard,Francoise Gueritte-Voegelein,Lydie. Mangatal,Pierre Potier +5 more
Journal Article
Experimental Antitumor Activity of Taxotere (RP 56976, NSC 628503), a Taxol Analogue
TL;DR: Taxotere was evaluated for antitumor activity against a variety of transplantable tumors of mice and effected greater than 80% complete regressions of advanced stage disease with both tumors.
Journal ArticleDOI
Taxol and taxotere: discovery, chemistry, and structure-activity relationships
Patent
Taxol derivatives, their preparation and pharmaceutical compositions containing them
TL;DR: Taxol derivatives of formula STR1 are useful antitumor agents as mentioned in this paper, in which R represents hydrogen or acetyl, one of R 1 or R 2 represents hydroxy and the other represents tert-butoxy carbonylamino.