F
François Lavelle
Researcher at Rhône-Poulenc
Publications - 64
Citations - 3531
François Lavelle is an academic researcher from Rhône-Poulenc. The author has contributed to research in topics: Topoisomerase & In vivo. The author has an hindex of 26, co-authored 64 publications receiving 3456 citations.
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Journal ArticleDOI
Relationships between the structure of taxol analogues and their antimitotic activity.
Francoise Gueritte-Voegelein,Daniel Guenard,François Lavelle,M.-T. Le Goff,L. Mangatal,Pierre Jean-Paul Potier +5 more
TL;DR: This structure-activity relationship study shows that inhibition of microtubule disassembly is quite sensitive to the configuration at C-2' and C-3'.
Journal Article
Experimental Antitumor Activity of Taxotere (RP 56976, NSC 628503), a Taxol Analogue
TL;DR: Taxotere was evaluated for antitumor activity against a variety of transplantable tumors of mice and effected greater than 80% complete regressions of advanced stage disease with both tumors.
Journal Article
Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine
Malcolm F. G. Stevens,John A. Hickman,Simon P. Langdon,David Chubb,Lisa M. Vickers,Robert Stone,Ghousia Baig,Colin Goddard,Neil W. Gibson,John Alfred Slack,Christopher Newton,Edward Lunt,Christian Fizames,François Lavelle +13 more
TL;DR: The 3-methyl analogue, 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045), was investigated further and found to possess good activity, when administered i.p. or p.o. to mice bearing the L1210 leukemia.
Journal Article
Preclinical evaluation of docetaxel (Taxotere).
François Lavelle,Marie-Christine Bissery,Cecile Combeau,Jean-François Riou,Patricia Vrignaud,S. Andre +5 more
TL;DR: Docetaxel has significant in vivo antitumor activity in the different models generally used for the preclinical evaluation of drugs and is cytotoxic at clinically relevant concentrations against fresh human tumor biopsy specimens in a soft agar cloning system.
Journal ArticleDOI
Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
Patricia Vrignaud,Dorothée Semiond,Pascale Lejeune,Herve Bouchard,Loreley Calvet,Cecile Combeau,Jean-François Riou,Alain Commercon,François Lavelle,Marie-Christine Bissery +9 more
TL;DR: Cabazitaxel is as active as docetaxel in docentaxel-sensitive tumor models but is more potent than docetAXel in tumor models with innate or acquired resistance to taxanes and other chemotherapies.