Daniel I. Benjamin

TL;DR: It is shown that microglia sense SFAs and orchestrate an inflammatory process in the MBH that alters neuronal function when SFA consumption is high, and in this context, microglial depletion enhances leptin signaling and reduces food intake.

TL;DR: It is found that pharmacological blockade of MAGL recapitulates the cytokine-lowering effects through reduced prostaglandin production, rather than enhanced endocannabinoid signaling, and put forth MAGL inhibitors as a potential next-generation strategy for combating AD.

TL;DR: It is demonstrated that ablation of AGPS in cancer cells results in reduced cell survival, cancer aggressiveness, and tumor growth through altering the balance of ether lipid, fatty acid, eicosanoid, and fatty acid–derived glycerophospholipid metabolism, resulting in an overall reduction in the levels of several oncogenic signaling lipids.

TL;DR: HIF-1α is identified as a novel regulator of IFN-γ–dependent immunity that coordinates an immunometabolic program essential for control of M. tuberculosis infection both in vitro and in vivo.

TL;DR: This review presents several examples of how large-scale profiling platforms have yielded fundamental insights into dysregulated metabolism in cancer and questions and challenges that must be addressed to more completely describe, and eventually control, the diverse metabolic pathways that support tumorigenesis.