Daniel L. Tuttle

TL;DR: It is proposed that CUGexp RNA causes two separate effects: loss of Mbnl1 function (disrupting splicing) and loss of another function that disrupts extracellular matrix mRNA regulation, possibly mediated by MbnL2.

TL;DR: It is demonstrated that relatively short CUGexp transcripts cause RNA gain-of-function effects and the growing number of antisense transcripts recently reported in mammalian genomes suggest unrecognized toxic RNAs contribute to the pathophysiology of polyglutamine CAG CTG disorders.

TL;DR: It is shown that there exist in P. pastoris at least two pathways for the sequestration of peroxisomes into the vacuole for degradation, and that protein synthesis is required forperoxisome entry into the yeast vacuoles during nutrient adaptation.

TL;DR: Levels of CCR5 were related to monocyte resistance and macrophage susceptibility to infection because infection by the M-tropic strain HIV-1JRFL could be blocked by MAb 2D7, and results provide direct evidence that C CR5 functions as a coreceptor for HIV- 1 infection of primary macrophages.

TL;DR: In cells treated with these drugs, the fractional volume represented by autophagic vaculoes was not substantially increased despite nutrient depletion, and nocodazole appeared to have no effect on the formation of autophagosomes.