Showing papers by "Daniel M. Brown published in 2006"
TL;DR: In this paper, the effect of introducing hydrogen bonding carboxamide groups onto the pyrrole ring of 5-nitroindole has been examined, and it was shown that the modified analogues retain universal base features, but there are no overall effects on duplex stability.
Abstract: A number of aromatic universal base analogues have been described in the literature, but most are non-hydrogen bonding. We have examined the effect of introducing hydrogen bonding carboxamide groups onto the pyrrole ring of 5-nitroindole. The modified analogues retain universal base features, but there are no overall effects on duplex stability. This leads to the suggestion that the nitro group is within the hydrogen bonding face of the duplex, and the hydrogen bonding carboxamide group is in the duplex major groove.
8 citations