D
Daniela Fraccarollo
Researcher at University of Würzburg
Publications - 63
Citations - 3834
Daniela Fraccarollo is an academic researcher from University of Würzburg. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 33, co-authored 59 publications receiving 3539 citations. Previous affiliations of Daniela Fraccarollo include Technische Universität München & Hannover Medical School.
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Journal ArticleDOI
Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress
Thomas Thum,Daniela Fraccarollo,Maximilian Schultheiss,Andreas Daiber,Philip Wenzel,Thomas Münzel,Georg Ertl,Johann Bauersachs +7 more
TL;DR: Compared the effects of 2 different nitrates on circulating EPC numbers and function, organic nitrates that improve EPC function may confer long-term cardiovascular protection based on their beneficial effects on EPC biology.
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Endothelial NO Synthase Target of Aldosterone
TL;DR: Aldosterone antagonism reduced vascular superoxide anion formation, and in combination with an angiotensin-converting enzyme inhibitor, increased the expression of the endothelial NO synthase (eNOS) and restored the …
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Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation.
Andreas Schäfer,Paolo Galuppo,Daniela Fraccarollo,Christian Vogt,Julian D. Widder,Julia Pfrang,Piet W.L. Tas,Eduardo Barbosa-Sicard,Hartmut Ruetten,Georg Ertl,Ingrid Fleming,Johann Bauersachs +11 more
TL;DR: Investigation of mechanisms underlying vascular endothelial and contractile dysfunction in diabetes as well as the effect of HMR1766, a novel nitric oxide (NO)-independent activator of soluble guanylyl cyclase (sGC) reduced oxidative stress, decreased CYP2E1 levels, and normalized vasomotor function in diabetic rats.
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Improvement of renal dysfunction in rats with chronic heart failure after myocardial infarction by treatment with the endothelin A receptor antagonist, LU 135252.
Johann Bauersachs,Claude Braun,Daniela Fraccarollo,Julian D. Widder,Georg Ertl,Lothar Schilling,Michael Kirchengast,Peter Rohmeiss +7 more
TL;DR: The data demonstrate a restoration of impaired renal function in chronic ischaemic heart failure by treatment with the selective ETA receptor antagonist, LU 135252, which offers a promising therapeutic option for the treatment of renal insufficiency in patients with chronic heart failure.
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Inhibition of platelet activation in rats with severe congestive heart failure by a novel endothelial nitric oxide synthase transcription enhancer.
Andreas Schäfer,Daniela Fraccarollo,Julian Widder,Martin Eigenthaler,Georg Ertl,Johann Bauersachs +5 more
TL;DR: This work investigated whether treatment with a novel endothelial NO synthase (eNOS)‐transcription enhancer positively modulates systemic NO bioavailability and reduces platelet activation in rats with CHF.