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Darren J. Mitchell
Researcher at University of Hertfordshire
Publications - 2
Citations - 66
Darren J. Mitchell is an academic researcher from University of Hertfordshire. The author has contributed to research in topics: Bromodomain & BRD4. The author has an hindex of 2, co-authored 2 publications receiving 37 citations.
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Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.
Christopher Roland Wellaway,Dominique Amans,Paul Bamborough,Heather Barnett,Rino A Bit,Jack A Brown,Neil R Carlson,Chun-wa Chung,Anthony W. J. Cooper,Peter D. Craggs,Robert P Davis,Tony W Dean,John Evans,Laurie Gordon,Isobel L Harada,David Jonathan Hirst,Philip G Humphreys,Katherine L Jones,Antonia J. Lewis,Matthew J Lindon,Dave Lugo,Mahnoor Mahmood,Scott McCleary,Patricia F Medeiros,Darren J. Mitchell,Michael O'Sullivan,Armelle Le Gall,Vipulkumar Kantibhai Patel,Chris Patten,Darren L Poole,Rishi R Shah,Jane E Smith,Kayleigh A J Stafford,Pamela J Thomas,Mythily Vimal,Ian D. Wall,Robert J. Watson,Natalie Wellaway,Gang Yao,Rab K. Prinjha +39 more
TL;DR: The bromodomain and extraterminal (BET) family of bromidomain-containing proteins are important regulators of the epigenome through their ability to recognize N-acetyl lysine post-translation.
Journal ArticleDOI
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype
Christopher Roland Wellaway,Paul Bamborough,Sharon G. Bernard,Chun-wa Chung,Peter D. Craggs,Leanne Cutler,Emmanuel Hubert Demont,John Evans,Laurie Gordon,Bhumika Karamshi,Antonia J. Lewis,Matthew J Lindon,Darren J. Mitchell,Inmaculada Rioja,Peter E. Soden,Simon Taylor,Robert J. Watson,Rob Willis,James M. Woolven,Beata S. Wyspiańska,William J. Kerr,Rab K. Prinjha +21 more
TL;DR: It is shown that selective inhibition of BD1 domains is sufficient to drive anti-inflammatory and antiproliferative effects and a potent probe molecule possessing up to 150-fold selectivity is discovered.