J
John Evans
Researcher at University of Hertfordshire
Publications - 5
Citations - 125
John Evans is an academic researcher from University of Hertfordshire. The author has contributed to research in topics: Electrode & Auxiliary electrode. The author has an hindex of 4, co-authored 5 publications receiving 96 citations.
Papers
More filters
Patent
Acidic gas sensors and method of using same
TL;DR: In this article, an electrochemical sensor for detecting carbon dioxide is presented. But it is not shown how to detect the presence of carbon dioxide in the electrolyte, only that it can be detected colorimetrically because it absorbs light at a different wavelength to the unmodified complex.
ComponentDOI
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.
Christopher Roland Wellaway,Dominique Amans,Paul Bamborough,Heather Barnett,Rino A Bit,Jack A Brown,Neil R Carlson,Chun-wa Chung,Anthony W. J. Cooper,Peter D. Craggs,Robert P Davis,Tony W Dean,John Evans,Laurie Gordon,Isobel L Harada,David Jonathan Hirst,Philip G Humphreys,Katherine L Jones,Antonia J. Lewis,Matthew J Lindon,Dave Lugo,Mahnoor Mahmood,Scott McCleary,Patricia F Medeiros,Darren J. Mitchell,Michael O'Sullivan,Armelle Le Gall,Vipulkumar Kantibhai Patel,Chris Patten,Darren L Poole,Rishi R Shah,Jane E Smith,Kayleigh A J Stafford,Pamela J Thomas,Mythily Vimal,Ian D. Wall,Robert J. Watson,Natalie Wellaway,Gang Yao,Rab K. Prinjha +39 more
TL;DR: The bromodomain and extraterminal (BET) family of bromidomain-containing proteins are important regulators of the epigenome through their ability to recognize N-acetyl lysine post-translation.
Journal ArticleDOI
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype
Christopher Roland Wellaway,Paul Bamborough,Sharon G. Bernard,Chun-wa Chung,Peter D. Craggs,Leanne Cutler,Emmanuel Hubert Demont,John Evans,Laurie Gordon,Bhumika Karamshi,Antonia J. Lewis,Matthew J Lindon,Darren J. Mitchell,Inmaculada Rioja,Peter E. Soden,Simon Taylor,Robert J. Watson,Rob Willis,James M. Woolven,Beata S. Wyspiańska,William J. Kerr,Rab K. Prinjha +21 more
TL;DR: It is shown that selective inhibition of BD1 domains is sufficient to drive anti-inflammatory and antiproliferative effects and a potent probe molecule possessing up to 150-fold selectivity is discovered.
Patent
Acidic gas sensors
TL;DR: In this article, an electrochemical sensor for detecting carbon dioxide is presented. But it is not shown how to detect the presence of carbon dioxide in the electrolyte, only that it can be detected colorimetrically because it absorbs light at a different wavelength to the unmodified complex.