Darren R. Head

TL;DR: A pattern of AR expression in malignant epithelium and adjacent stroma that is associated with a poor clinical outcome in prostate cancer is identified and the need to further investigate the mechanistic basis of loss of ARexpression in the malignant stroma and its potential role in deregulation of prostate epithelial cell proliferation is identified.

TL;DR: Aberrant protein expression of these cell cycle regulatory genes in IPMT and pancreatic intraepithelial neoplasia in the current model of pancreatic cancer progression suggest similarities in their development and may also represent the subsequent risk of invasive carcinoma.

TL;DR: Prognostic indicators in pancreatic cancer are poorly defined and difficult to quantify preoperatively, hence they may lead to inappropriate patient selection for treatment and accurate assessment of DPC4/Smad4 expression, unlike tumor size, margin status, and perineural invasion, does not require resection.

TL;DR: It is demonstrated that aberrant expression of key cell cycle regulatory genes may be important in the early development and progression of PanIN and p21(WAF1/CIP1) overexpression, independent of p53 and/or DPC4/Smad4 expression, may reflect increased Ras activity.

TL;DR: The presence of clusters of p53-positive nuclei delineates a group of patients with poor prognosis not identified by traditional scoring methods and supports the hypothesis that p53 dysfunction within PCa may exist in foci of tumor cells that are clonally expanded in metastases.