In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro antimicrobial activity of various 3-(1,3,4-oxadiazol-2-yl)-quinazolin-4(3H)-ones. The antimicrobial activity of title compounds were examined against two gram positive bacteria (S. aureus, S. pyogenes), two gram negative bacteria (E. coli, P. aeruginosa) and three fungi (C. albicans, A. niger, A. clavatus) using the broth microdilution method. Some derivatives bearing a bromo or iodo group exhibited very good antimicrobial activity.

https://www.mdpi.com/2218-0532/78/2/171/pdf

Synthesis and antimicrobial activity of 3-(1,3,4-oxadiazol-2-yl)quinazolin-4(3H)-ones.

Synthesis and evaluation of substituted quinazolone derivatives for antibacterial, antifungal, and antiacetylcholinesterase activities

A number of quinazolin-4(3H)-one carbothioamides, pyrazoles, pyrazolones and tetrazole derivatives have been synthesised by the reaction of 2-hydrazino-3-(4-substituted phenyl)-quinazolin-4(3H)-ones with the appropriate aryl isothiocyanate, acetyl acetone, ethylacetoacetate and nitrous acid. All the compounds were tested in vitro for antibacterial, insecticidal and antifungal activity and found to have some activity.

Synthesis and pesticidal activity of some quinazolin‐4(3H)‐one derivatives

Pharmacological Studies on Quaternized 4(3H)-Quinazolinones

Quinazoline (I) is the building stone for approximately fifty naturally occurring alkaloids isolated from a number of different families of the plant kingdom, from microorganisms and animals [1]. The best known quinazoline alkaloids are peganine (vasicine) (II, R=H) and febrifugine (III).

Daulat S. Mehta

Papers

Fluorinated quinazolones III: synthesis and CNS depressant activity of fluorinated quinazolone derivatives.