David Bakish

TL;DR: The data indicate that NUDR is a repressor of the 5-HT1A receptor in raphe cells the function of which is abrogated by a promoter polymorphism, suggesting a novel transcriptional model in which the G(-1019) allele derepresses 5- HT1A autoreceptor expression to reduce serotonergic neurotransmission, predisposing to depression and suicide.

TL;DR: The results implicate the C(-1019)G 5- HT1A gene polymorphism as a potential marker for antidepressant response, suggesting a role for repression of the 5-HT1A genes.

TL;DR: The results suggest that upregulation of platelet 5-HT2 receptors is a useful biological marker in major depression, particularly in females.

TL;DR: Paroxetine appears to produce an earlier improvement in agitation and psychic anxiety symptoms compared with fluoxetined, and differences observed between the two drugs in antianxiety effects were limited to two measures of anxiety among several others.

TL;DR: The major finding was that patients suffering from their first depressive episode differed from patients with recurrent depressive episodes in the rate of placebo response, effect of gender, and the clinical symptoms that were associated with a positive placebo response.