L
Lisheng Du
Researcher at Ottawa Hospital
Publications - 3
Citations - 1067
Lisheng Du is an academic researcher from Ottawa Hospital. The author has contributed to research in topics: Genotype & Polymorphism (computer science). The author has an hindex of 3, co-authored 3 publications receiving 1030 citations. Previous affiliations of Lisheng Du include McGill University.
Papers
More filters
Journal ArticleDOI
Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide
Sylvie Lemonde,Gustavo Turecki,David Bakish,Lisheng Du,Pavel D. Hrdina,Christopher D. Bown,Adolfo Sequeira,Neena Kushwaha,Stephen J. Morris,Ajoy Basak,Xiao-Ming Ou,Paul R. Albert +11 more
TL;DR: The data indicate that NUDR is a repressor of the 5-HT1A receptor in raphe cells the function of which is abrogated by a promoter polymorphism, suggesting a novel transcriptional model in which the G(-1019) allele derepresses 5- HT1A autoreceptor expression to reduce serotonergic neurotransmission, predisposing to depression and suicide.
Journal ArticleDOI
Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response.
TL;DR: The results implicate the C(-1019)G 5- HT1A gene polymorphism as a potential marker for antidepressant response, suggesting a role for repression of the 5-HT1A genes.
Journal ArticleDOI
Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims
Lisheng Du,Gabor Faludi,Miklós Palkovits,Elizabeth Demeter,David Bakish,Yvon D. Lapierre,Péter Sótonyi,Pavel D. Hrdina +7 more
TL;DR: A significantly higher frequency of the 5-HT transporter gene long (L) allele in depressed suicides is found, providing the first evidence suggesting that a functional polymorphism in the regulatory region of serotonin transporter gene may be associated with suicide in depressed subjects.