D
David Bernhard
Researcher at Johannes Kepler University of Linz
Publications - 103
Citations - 5861
David Bernhard is an academic researcher from Johannes Kepler University of Linz. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 38, co-authored 100 publications receiving 5150 citations. Previous affiliations of David Bernhard include University of Innsbruck & Medical University of Vienna.
Papers
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Journal ArticleDOI
Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis.
Barbara Messner,David Bernhard +1 more
TL;DR: The present review aims at providing a comprehensive summary of published data from clinical and animal studies, as well as results of basic research on the proatherogenic effect of smoking, to suggest the most effective measure for reversing damage that has already occurred and preventing fatal cardiovascular outcomes.
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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
Astrid A. Ruefli,Michael J. Ausserlechner,David Bernhard,Vivien R. Sutton,Kellie M. Tainton,Reinhard Kofler,Mark J. Smyth,Ricky W. Johnstone +7 more
TL;DR: Evidence is provided of a mechanism of cell death mediated by transcriptional events that result in the cleavage of Bid, disruption of the mitochondrial membrane, and production of reactive oxygen species to induce cell death.
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Cadmium Is a Novel and Independent Risk Factor for Early Atherosclerosis Mechanisms and In Vivo Relevance
Barbara Messner,Michael Knoflach,Andreas Seubert,Andreas Ritsch,Kristian Pfaller,Blair Henderson,Ying H. Shen,Iris Zeller,Johann Willeit,Günther Laufer,Georg Wick,Stefan Kiechl,David Bernhard +12 more
TL;DR: Cd has promoting effects on early human and murine atherosclerosis, which were partly offset by high Zn concentrations, which showed a potent protective effect against deleterious effects of Cd both in the in vitro and human studies.
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The biology behind the atherothrombotic effects of cigarette smoke.
Adam Csordas,David Bernhard +1 more
TL;DR: Public health efforts should urgently promote the understanding of current cigarette-smoke-induced cardiovascular pathology to encourage individuals to reduce their exposure to cigarette smoke and, therefore, the detrimental consequences of associated atherothrombotic disease.
Journal ArticleDOI
Metals in cigarette smoke.
TL;DR: This review focuses on the consequences of metal delivery to the human body by cigarette smoking and discusses the body's responses, and links individual cigarette smoke contained metals to the genesis of human diseases.