Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous stream rather than in a flask Flow equipment provides chemists with unique control over reaction parameters enhancing reactivity or in some cases enabling new reactions This relatively young technology has received a remarkable amount of attention in the past decade with many reports on what can be done in flow Until recently, however, the question, “Should we do this in flow?” has merely been an afterthought This review introduces readers to the basic principles and fundamentals of flow chemistry and critically discusses recent flow chemistry accounts

The Hitchhiker's Guide to Flow Chemistry

Recent advances in the preparation and synthetic applications of oxiranes

Aromatic organolithium reagents bearing electrophilic groups. Preparation by halogen-lithium exchange

Cyclization Reactions of Dianions in Organic Synthesis

Cellular screening of various synthetic triterpenoid compounds formally derived from lupane has identified a number of analogues as potential anticancer drug candidates. Here we describe the synthesis and structure-activity relationships of betulin and betulinic acid derivatives containing an E-ring modified with different oxygen functions. Thus compounds containing the lup-18-en-21-one, lup-18-ene-21,22-dione, 18,19-secolupane, and the highly oxygenated 18,19-secolupane systems, as well as des-E-lupane derivatives, were prepared from the readily available natural pentacyclic triterpene betulin using oxidative procedures. These compounds were named betulinines. We demonstrate that only selected compounds, particularly those containing a lupane E-ring-derived unsaturated ketone or diketone function, possessed in vitro cytotoxic activity against tumor cell lines, suggesting a structure-activity relationship.

New lupane derived compounds with pro-apoptotic activity in cancer cells: synthesis and structure-activity relationships.

Oxygen heterocycles by the Parham cyclialkylation

Aus den Phenylhydrazonen (I) entstehen die Dilithio-Derivate (II), die mit den Saurechloriden (III) uber die Zwischenstufen (IV)-(VII) zu den 4-Acylpyrazolen (VIII) cyclisiert werden.

New method for the preparation of 4-acylpyrazoles. Reaction of C(.alpha.),N dianions of phenylhydrazones with acid chlorides

A new anionic cyclization of the Parham type. Selective ring opening of epoxides

The reactions of C(α), O-dilithiooximes, C(α), N-dilithiophenylhydrazones, and C(α), N,N-trilithiohydrazones with diethyl oxalate to give biisoxazoles, bipyrazoles, and pyridazones

David C. Reames

Papers

Oxygen heterocycles by the Parham cyclialkylation

New method for the preparation of 4-acylpyrazoles. Reaction of C(.alpha.),N dianions of phenylhydrazones with acid chlorides

A new anionic cyclization of the Parham type. Selective ring opening of epoxides

The reactions of C(α), O-dilithiooximes, C(α), N-dilithiophenylhydrazones, and C(α), N,N-trilithiohydrazones with diethyl oxalate to give biisoxazoles, bipyrazoles, and pyridazones

Reactions of c(α),N-dilithiophenylhydrazones with aldehydes. Acid-cyclization to 2-pyrazolines