D
David D. Allen
Researcher at Northeastern University
Publications - 72
Citations - 5029
David D. Allen is an academic researcher from Northeastern University. The author has contributed to research in topics: Choline transporter & Choline. The author has an hindex of 35, co-authored 72 publications receiving 4671 citations. Previous affiliations of David D. Allen include Texas Tech University & University of Kentucky.
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Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability
TL;DR: In this article, the effect of neutral, anionic and cationic charged nanoparticles on the blood-brain barrier (BBB) and brain permeability was evaluated by in situ rat brain perfusion.
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Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier
TL;DR: NP technology appears to have significant promise in delivering therapeutic molecules across the blood-brain barrier and primary methods of NP preparation and characterization are described.
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Paclitaxel nanoparticles for the potential treatment of brain tumors
TL;DR: It was hypothesized that PX NPs could mask paclitaxel characteristics and thus limit its binding to p-gp, which consequently would lead to higher brain and tumor cell uptake of the otherwise effluxed drug.
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Brain uptake of thiamine-coated nanoparticles
Paul R. Lockman,Moses O. Oyewumi,Koziara Joanna M,Karen E. Roder,Russell J. Mumper,David D. Allen +5 more
TL;DR: Thiamine ligand facilitated binding and/or association with blood-brain barrier thiamine transporters, which may be a viable mechanism for nanoparticle mediated brain drug delivery.
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In situ blood-brain barrier transport of nanoparticles.
TL;DR: For both nanoparticle types, statistically significant uptake was observed compared to [14C]sucrose, suggesting central nervous system uptake of nanoparticles, suggesting the mechanism underlying the nanoparticle brain uptake has yet to be fully understood.