D
David E. Kling
Researcher at Harvard University
Publications - 30
Citations - 2639
David E. Kling is an academic researcher from Harvard University. The author has contributed to research in topics: Kinase & Epitope. The author has an hindex of 19, co-authored 29 publications receiving 2065 citations. Previous affiliations of David E. Kling include Brigham and Women's Hospital & United States Department of Veterans Affairs.
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Scaling accurate genetic variant discovery to tens of thousands of samples
Ryan Poplin,Ruano-Rubio,Mark A. DePristo,Timothy Fennell,Mauricio O. Carneiro,Van der Auwera Ga,David E. Kling,Laura D. Gauthier,Ami Levy-Moonshine,David Roazen,Khalid Shakir,Thibault J,Chandran S,Christopher W. Whelan,Monkol Lek,Stacey Gabriel,Mark J. Daly,Neale Bm,Daniel G. MacArthur,Eric Banks +19 more
TL;DR: A novel assembly-based approach to variant calling, the GATK HaplotypeCaller and Reference Confidence Model, that determines genotype likelihoods independently per-sample but performs joint calling across all samples within a project simultaneously, showing that the accuracy of indel variant calling is superior in comparison to other algorithms.
Journal ArticleDOI
The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota
Zhuoteng Yu,Ceng Chen,David E. Kling,Bo Liu,John M. Mccoy,Massimo Merighi,Matthew Ian Heidtman,David S. Newburg +7 more
TL;DR: If these bifidobacteria are representative of pioneering or keystone species for human microbiota, fucosylated HMOS could strongly promote colonization and maintenance of a mutualist symbiotic microbiome.
Journal ArticleDOI
The human milk oligosaccharide 2′-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation
Yingying He,Shubai Liu,David E. Kling,Serena Leone,Nathan Lawlor,Yi Huang,Samuel B Feinberg,David R. Hill,David S. Newburg +8 more
TL;DR: In this paper, the authors investigated whether human milk oligosaccharides (HMOSs) influence pathogenic Escherichia coli -induced interleukin (IL)-8 release by intestinal epithelial cells (IECs).
Journal ArticleDOI
Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci.
Michel James L,Lawrence C. Madoff,Kristin Olson,David E. Kling,Dennis L. Kasper,Frederick M. Ausubel +5 more
TL;DR: The C protein alpha antigen structural gene (named bca for group B, C protein, alpha) is cloned into Escherichia coli and demonstrates a regularly laddered pattern of heterogeneous polypeptides.
Journal ArticleDOI
Group B streptococci escape host immunity by deletion of tandem repeat elements of the alpha C protein.
TL;DR: Deletions in the repeat region were observed at a much lower frequency and appear to lower the organism's susceptibility to killing by antibody specific to the alpha C protein, suggesting this mechanism of antigenic variation may provide a means whereby GBS evade host immunity.