D
David F. Savage
Researcher at University of California, Berkeley
Publications - 97
Citations - 4791
David F. Savage is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Biology & RuBisCO. The author has an hindex of 30, co-authored 80 publications receiving 3579 citations. Previous affiliations of David F. Savage include Harvard University & University of California, San Francisco.
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Journal ArticleDOI
Spatially Ordered Dynamics of the Bacterial Carbon Fixation Machinery
TL;DR: It is shown that carboxysomes are linearly arranged within the cytoplasm in a process that involves the bacterial cytoskeleton, an organelle-like proteinaceous microcompartment that sequesters the enzymes of carbon fixation from the cy toplasm.
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Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z
David F. Savage,Pascal F. Egea,Yaneth Robles-Colmenares,Joseph D. O'Connell,Robert M. Stroud +4 more
TL;DR: The X-ray structure of AqpZ is to the authors' knowledge the first atomic resolution structure of a recombinant aquaporin and provides a platform for combined genetic, mutational, functional, and structural determinations of the mechanisms of aquaporins and, more generally, the assembly of multimeric membrane proteins.
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Substrate twinning activates the signal recognition particle and its receptor
Pascal F. Egea,Shu-ou Shan,Shu-ou Shan,Johanna Napetschnig,David F. Savage,Peter Walter,Peter Walter,Robert M. Stroud +7 more
TL;DR: To define the mechanism of reciprocal activation, the 1.9 Å structure of the complex formed between these two GTPases was determined, and the two partners form a quasi-two-fold symmetrical heterodimer.
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Engineering Cyanobacteria To Synthesize and Export Hydrophilic Products
Henrike Niederholtmeyer,Bernd T. Wolfstädter,David F. Savage,Pamela A. Silver,Pamela A. Silver,Jeffrey C. Way +5 more
TL;DR: Results indicate that cyanobacteria can be engineered to produce and secrete high-value hydrophilic products and could be used to support Escherichia coli growth in the absence of additional nutrient sources.
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Modularity of a carbon-fixing protein organelle
Walter Bonacci,Poh K. Teng,Bruno Afonso,Henrike Niederholtmeyer,Patricia Grob,Pamela A. Silver,David F. Savage +6 more
TL;DR: It is shown that carboxysomes, CO2-fixing microcompartments encoded by 10 genes, can be heterologously produced in Escherichia coli and laid the groundwork for understanding these elaborate protein complexes and for the synthetic biological engineering of self-assembling molecular structures.