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Pamela A. Silver
Researcher at Harvard University
Publications - 403
Citations - 37409
Pamela A. Silver is an academic researcher from Harvard University. The author has contributed to research in topics: Nuclear protein & Nuclear transport. The author has an hindex of 106, co-authored 398 publications receiving 34242 citations. Previous affiliations of Pamela A. Silver include University of California, Santa Cruz & University of California, Berkeley.
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Genome-wide analysis of estrogen receptor binding sites
Jason S. Carroll,Clifford A. Meyer,Jun S. Song,Wei Li,Timothy R. Geistlinger,Jérôme Eeckhoute,Alexander S. Brodsky,Erika Krasnickas Keeton,Kirsten C Fertuck,Giles Hall,Qianben Wang,Stefan Bekiranov,Stefan Bekiranov,Victor Sementchenko,Edward A. Fox,Pamela A. Silver,Thomas R. Gingeras,X. Shirley Liu,Myles Brown +18 more
TL;DR: All estrogen receptor and RNA polymerase II binding sites are mapped on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells, and distinct temporal mechanisms of estrogen-mediated gene regulation are demonstrated.
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Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1
Jason S. Carroll,X. Shirley Liu,Alexander S. Brodsky,Wei Li,Clifford A. Meyer,Anna J. Szary,Jérôme Eeckhoute,Wenlin Shao,Eli V. Hestermann,Timothy R. Geistlinger,Edward A. Fox,Pamela A. Silver,Myles Brown +12 more
TL;DR: The unbiased sequence interrogation of the genuine chromatin binding sites suggests that direct ER binding requires the presence of Forkhead factor binding in close proximity, demonstrating the necessity of FoxA1 in mediating an estrogen response in breast cancer cells.
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Water splitting–biosynthetic system with CO2 reduction efficiencies exceeding photosynthesis
TL;DR: A hybrid water splitting–biosynthetic system based on a biocompatible Earth-abundant inorganic catalyst system to split water into molecular hydrogen and oxygen at low driving voltages that has a CO2 reduction energy efficiency exceeding that of natural photosynthetic systems.
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Toehold Switches: De-Novo-Designed Regulators of Gene Expression
TL;DR: A class of de-novo-designed prokaryotic riboregulators called toehold switches are reported that activate gene expression in response to cognate RNAs with arbitrary sequences that represent a versatile and powerful platform for regulation of translation.
Journal ArticleDOI
Organization of Intracellular Reactions with Rationally Designed RNA Assemblies
Camille J. Delebecque,Ariel B. Lindner,Ariel B. Lindner,Pamela A. Silver,Pamela A. Silver,Faisal A. Aldaye,Faisal A. Aldaye +6 more
TL;DR: Rationally designed RNA assemblies can thus be used to construct functional architectures in vivo and increased hydrogen output as a function of scaffold architecture.