D
David Fraguas
Researcher at Hospital General Universitario Gregorio Marañón
Publications - 77
Citations - 2460
David Fraguas is an academic researcher from Hospital General Universitario Gregorio Marañón. The author has contributed to research in topics: First episode & Psychosis. The author has an hindex of 25, co-authored 71 publications receiving 1926 citations. Previous affiliations of David Fraguas include Complutense University of Madrid & Hospital Clínico San Carlos.
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Journal ArticleDOI
Predictors of outcome in early-onset psychosis: a systematic review.
Covadonga M. Díaz-Caneja,Laura Pina-Camacho,Alberto Rodríguez-Quiroga,David Fraguas,Mara Parellada,Celso Arango +5 more
TL;DR: EOP patients with poorer premorbid adjustment and prominent negative symptoms at initial presentation are at risk of poor outcome and should be the target of careful monitoring and more intensive interventions to address whether the disease course can be modified in this especially severely affected group.
Journal ArticleDOI
Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons.
David Fraguas,Christoph U. Correll,Jessica Merchán-Naranjo,Marta Rapado-Castro,Mara Parellada,Carmen Moreno,Celso Arango +6 more
TL;DR: SGAs do not behave as a homogeneous group in children and adolescents with psychotic and mood disorders, and the heterogeneity within the SGA group is mainly due to differences in the rates and severity of adverse events, especially regarding weight gain as a proxy for the risk of cardiometabolic disturbances.
Journal ArticleDOI
Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-analysis.
David Fraguas,David Fraguas,Covadonga M. Díaz-Caneja,Covadonga M. Díaz-Caneja,Miriam Ayora,Miriam Ayora,Fabián Hernández-Álvarez,Alberto Rodríguez-Quiroga,Sandra Recio,Sandra Recio,Juan C. Leza,Juan C. Leza,Celso Arango,Celso Arango +13 more
TL;DR: A systematic literature search of cross-sectional studies comparing in vivo inflammatory and oxidative blood markers between FEP patients and healthy controls showed that FEP Patients had reduced antioxidant status and a pro-inflammatory imbalance, and that these biological processes may be targets for managing FEP.
Journal ArticleDOI
Differential Neurodevelopmental Trajectories in Patients With Early-Onset Bipolar and Schizophrenia Disorders
TL;DR: It is suggested that some of these abnormal developmental trajectories are more related to the phenotypic features (eg, early-onset psychotic symptoms) of these 2 syndromes than to categorically defined Diagnostic and Statistical Manual of Mental Disorders disorders.
Journal ArticleDOI
Reduced antioxidant defense in early onset first-episode psychosis: a case-control study
Juan Antonio Mico,M.O. Rojas-Corrales,Juan Gibert-Rahola,Mara Parellada,Dolores Moreno,David Fraguas,Montserrat Graell,Javier Gil,Jon Irazusta,Josefina Castro-Fornieles,Cesar Soutullo,Celso Arango,Soraya Otero,Ana Navarro,Inmaculada Baeza,Mónica Martínez-Cengotitabengoa,Ana González-Pinto +16 more
TL;DR: This study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients, and glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia.