Hydrogel: Preparation, characterization, and applications: A review

Hydrogels in pharmaceutical formulations.

Hydrogel Nanoparticles in Drug Delivery

Novel crosslinking methods to design hydrogels

On the importance and mechanisms of burst release in matrix-controlled drug delivery systems

Gradient polyacrylamide gel electrophoresis for determination of molecular weights of heparin preparations and low-molecular-weight heparin derivatives.

A variety of enzymes have been found to acylate sucrose in anhydrous pyridine. The enzymic reaction is highly selective; with trifluoroethylbutyrate as ester donor, enzyme-catalyzed transesterification of sucrose yielded sucrose 1'-butyrate and sucrose 6, 1'-dibutyrate. No sucrose-tributyrates were formed. Using a similar technique, a long-chain linear sucrose polyester has been prepared using Proleather, an alkaline protease from a Bacillus sp. This protease catalyzes the esterification of sucrose with bis(2, 2, 2-trifluoroethyladipate) in a 1:1 ratio to yield a sucrose-containing polyester with M(w) = 2100 and M(n) = 1600 for a polydispersity of 1. 31. Polymers with molecular weights in excess of 13, 000 have been prepared by this enzymic approach, indicating that molecules containing over 30 sucrose units have been produced. The polyester is extremely water soluble and soluble in polar organic solvents. As with the sucrose dibutyrate, the polyester has ester linkages at the C6 and C1' positions on the sucrose. The polyester can be depolymerized using Proleather in aqueous buffer, pH7. After 9 days in aqueous buffer, Proleather catalyzed the breakdown of the polyester to an M(w) of ca. 900. This sucrose-containing polyester may have applications as a water-absorbent, biodegradable plastic for use as diapers and hygienic products, water-treatment chemicals, and components of drug delivery systems.

Enzymatic synthesis of a sucrose‐containing linear polyester in nearly anhydrous organic media

The effects of metal-oxygen bond strength on properties of oxides: II. Water-gas shift over bulk oxides

Macroporous poly(sucrose acrylate) hydrogel for controlled release of macromolecules.

Enzymatic and chemoenzymatic approaches to synthesis of sugar-based polymer and hydrogels

David G. Rethwisch

Papers

Gradient polyacrylamide gel electrophoresis for determination of molecular weights of heparin preparations and low-molecular-weight heparin derivatives.

Enzymatic synthesis of a sucrose‐containing linear polyester in nearly anhydrous organic media

The effects of metal-oxygen bond strength on properties of oxides: II. Water-gas shift over bulk oxides

Macroporous poly(sucrose acrylate) hydrogel for controlled release of macromolecules.

Enzymatic and chemoenzymatic approaches to synthesis of sugar-based polymer and hydrogels