D
David Gravestock
Researcher at Syngenta
Publications - 35
Citations - 794
David Gravestock is an academic researcher from Syngenta. The author has contributed to research in topics: Ring (chemistry) & Indolizidine. The author has an hindex of 11, co-authored 35 publications receiving 723 citations. Previous affiliations of David Gravestock include Council of Scientific and Industrial Research & University of KwaZulu-Natal.
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Journal ArticleDOI
New developments in the Peterson olefination reaction.
TL;DR: The strong affinity of the oxygen anion for the silyl moiety is emphasised when the Peterson olefination reaction takes preference over both the Julia and Wittig reactions in the presence of S- and P-stabilised sily l carbanions.
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Enaminones: versatile intermediates for natural product synthesis*
Joseph P. Michael,C. B. De Koning,David Gravestock,Gladys D. Hosken,Arthur S. Howard,C. M. Jungmann,Rui W. M. Krause,Andrew S. Parsons,Stephen C. Pelly,Trevor V. Stanbury +9 more
TL;DR: In this article, an overview of the chemistry of enaminones and related compounds containing the structural unit N-CaC-Z (Za COR, CO2R, CN, NO2, S O 2Ar, etc.).
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Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors
Moira L. Bode,David Gravestock,Simon Sana Moleele,Christiaan W. van der Westhuyzen,Stephen C. Pelly,Paul A. Steenkamp,Heinrich C. Hoppe,Tasmiyah Khan,Lindiwe A. Nkabinde +8 more
TL;DR: During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase and showed good inhibitory activity in enzymatic (RT) and HIV anti-infectivity MAGI whole cell assays.
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Silver-catalysed hydroamination : synthesis of functionalised pyrroles.
TL;DR: In this article, it was shown that functionalised pyrroles can be efficiently prepared using a two-step sequence using n-BuLi and propargyl bromide.
Journal ArticleDOI
Silver‐Catalyzed Hydroamination: Synthesis of N‐Bridgehead Pyrroles, Incorporating a Protection‐Deprotection Strategy for Preparation of Cyclic Secondary Vinylogous Carbamates
TL;DR: In this article, N-bridgehead pyrroles are efficiently prepared from cyclic secondary vinylogous carbamates using a two-step sequence, which involves C-propargylation followed by a silver-catalyzed intramolecular hydroamination.