David Hardisson

TL;DR: The data indicate that in breast tumors, EMT likely occurs within a specific genetic context, the basal phenotype, and suggests that this proclivity to mesenchymal transition may be related to the high aggressiveness and the characteristic metastatic spread of these tumors.

TL;DR: A suite of highly reproducible tumor microplate three-dimensional functional assays are established and validated to enhance the biological relevance of early preclinical cancer studies and increase the translational predictive value of in vitro drug evaluation studies and reduce the need for in vivo studies by more effective triaging of compounds.

TL;DR: Basal-like tumors had a tendency towards visceral metastasis and their prognosis was dependent on the use of postoperative chemotherapy, and fascin expression was associated with the basal-like phenotype, but not with prognosis or recurrence pattern.

TL;DR: Advances in the understanding of the molecular basis of HNSCC will help in the identification of new molecular markers that could be used for a more accurate diagnosis and assessment of prognosis and may open the way for novel approaches to treatment and prevention.

TL;DR: Inhibition of FGFR1 expression using small interfering RNA or a small-molecule chemical inhibitor showed thatFGFR1 signaling contributes to the survival of MDA-MB-134 cells.