D
David Hendlin
Researcher at Merck & Co.
Publications - 53
Citations - 2397
David Hendlin is an academic researcher from Merck & Co.. The author has contributed to research in topics: Cephamycin & Cefoxitin. The author has an hindex of 23, co-authored 53 publications receiving 2327 citations.
Papers
More filters
Journal ArticleDOI
Phosphonomycin, a New Antibiotic Produced by Strains of Streptomyces
David Hendlin,Edward O. Stapley,M. Jackson,Hyman Wallick,Miller Ak,Frank J. Wolf,Thomas W. Miller,Louis Chaiet,Frederick M. Kahan,Eldon L. Foltz,H. B. Woodruff,J.M. Mata,Sebastian Hernandez,Sagrario Mochales +13 more
TL;DR: Phosphonomycin is a newly discovered antibiotic produced by streptomycetes that is effective, when administered by the oral route, to mice infected with Gram-positive or Gram-negative microorganisms.
Journal ArticleDOI
Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.
Jean S. Kahan,Frederick M. Kahan,Robert T. Goegelman,Sara A. Currie,M. Jackson,Edward O. Stapley,Thomas W. Miller,Miller Ak,David Hendlin,Sagrario Mochales,Sebastian Hernandez,H. B. Woodruff,Jerome Birnbaum +12 more
TL;DR: A new beta-lactam antibiotic, named thienamycin, was discovered in culture broths of Streptomyces MA4297, and subsequently determined to be a hitherto unrecognized species, is designated StrePTomyces cattleya (NRRL 8057).
Journal ArticleDOI
Cephamycins, a New Family of β-Lactam Antibiotics I. Production by Actinomycetes, Including Streptomyces lactamdurans sp. n
Edward O. Stapley,M. Jackson,Sebastian Hernandez,Sheldon B. Zimmerman,Sara A. Currie,Sagrario Mochales,Mata Justo M,H. B. Woodruff,David Hendlin +8 more
TL;DR: A number of actinomycetes isolated from soil were found to produce one or more members of a new family of antibiotics, the cephamycins, which are structurally related to cephalosporin C.
Journal ArticleDOI
Cefoxitin, a Semisynthetic Cephamycin Antibiotic: Resistance to Beta-Lactamase Inactivation
TL;DR: The role of the constitutive and inducible enzyme in bacterial resistance to the antibiotic was investigated and enzymatic destruction of cefoxitin was found to be an important factor contributing to bacterial resistance.
Journal ArticleDOI
Cefoxitin, a Semisynthetic Cephamycin Antibiotic: Susceptibility Studies
Hyman Wallick,David Hendlin +1 more
TL;DR: Cefoxitin, 3-carbamoyloxymethyl-7-α-methoxy-7-[2-thienyl)acetamido]-3-cephem-4- carboxylic acid, is a new semisynthetic cephamycin with broad antibacterial activity.