D
David I. Graham
Researcher at Southern General Hospital
Publications - 304
Citations - 28025
David I. Graham is an academic researcher from Southern General Hospital. The author has contributed to research in topics: Head injury & Cerebral blood flow. The author has an hindex of 88, co-authored 304 publications receiving 27155 citations. Previous affiliations of David I. Graham include University of Glasgow & University of California.
Papers
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Journal ArticleDOI
Diffuse axonal injury and traumatic coma in the primate
Thomas A. Gennarelli,Lawrence E. Thibault,J H Adams,David I. Graham,C J Thompson,R. P. Marcincin +5 more
TL;DR: It is concluded that axonal damage produced by coronal head acceleration is a major cause of prolonged traumatic coma and its sequelae and is identical to that seen in severe head injury in humans.
Book
Greenfield's Neuropathology
TL;DR: Tumours of the Meninges Arie Perry Mesenchymal Non-Meningothelial Tumours Christine E. Fuller Hereditary Tumour Syndromes Aie Perry Paraneoplastic Syndrome Marc K. Rosenblum CNS Reactions to Anti-Neoplastic Therapies AriePercy Perry.
Journal ArticleDOI
Diffuse axonal injury in head injury: definition, diagnosis and grading.
TL;DR: Diffuse axonal injury was identified in 122 of a series of 434 fatal non‐missile head injuries–‐10 grade 1, 29 grade 2 and 83 grade 3; in 24 of these cases the diagnosis could not have been made without microscope examination, while in a further 31 microscopical examination was required to establish its severity.
Journal ArticleDOI
Diffuse axonal injury due to nonmissile head injury in humans: an analysis of 45 cases.
TL;DR: The available evidence indicates that DAI in human beings occurs at the time of head injury and is not due to complicating factors such as hypoxia, brain swelling, or raised intracranial pressure.
Journal ArticleDOI
Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression
W. S. T. Griffin,J. G. Sheng,J. G. Sheng,M.C. Royston,S.M. Gentleman,J.E. McKenzie,David I. Graham,G.W. Roberts,Robert E. Mrak +8 more
TL;DR: The hypothesis that chronic activation of glial inflammatory processes, arising from genetic or environmental insults to neurons and accompanied by chronic elaboration of neuroactive glia‐derived cytokines and other proteins, sets in motion a cytokine cycle of cellular and molecular events with neurodegenerative consequences is advanced.