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David J. Bennett
Researcher at University of Alberta
Publications - 102
Citations - 7760
David J. Bennett is an academic researcher from University of Alberta. The author has contributed to research in topics: Spinal cord injury & Spinal cord. The author has an hindex of 45, co-authored 101 publications receiving 7101 citations. Previous affiliations of David J. Bennett include Massachusetts Institute of Technology & University of Copenhagen.
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Time-varying stiffness of human elbow joint during cyclic voluntary movement
TL;DR: Overall, the moving arm was found to be very compliant, with a peak stiffness value less than the lowest value measured during posture, and a natural frequency of less than 3 Hz.
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Persistent inward currents in motoneuron dendrites: implications for motor output
TL;DR: The brainstem neuromodulatory input provides a mechanism by which the excitability of motoneurons can be varied for different motor behaviors, which is lost in spinal cord injury but PICs nonetheless recover near‐normal amplitudes in the months following the initial injury.
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Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors
Katherine C. Murray,Aya Nakae,Marilee J. Stephens,Michelle M. Rank,Jessica M. D'Amico,P. J. Harvey,X. Li,R. Luke Harris,Edward W Ballou,Roberta Anelli,Charles J. Heckman,Takashi Mashimo,Romana Vavrek,Leo Sanelli,Monica A. Gorassini,David J. Bennett,Karim Fouad +16 more
TL;DR: Blocking constitutively active 5-HT2C receptors with SB206553 or cyproheptadine in both rats and humans largely eliminates these calcium currents and muscle spasms, providing a new rationale for antispastic drug therapy.
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Persistent Sodium and Calcium Currents Cause Plateau Potentials in Motoneurons of Chronic Spinal Rats
Y. Li,David J. Bennett +1 more
TL;DR: Low-threshold persistent calcium (Cav1.3) and sodium currents spontaneously develop in motoneurons of chronic spinal rats and these enable large, rapidly activated plateaus that ultimately lead to spasticity.
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Role of Persistent Sodium and Calcium Currents in Motoneuron Firing and Spasticity in Chronic Spinal Rats
TL;DR: Both the calcium and sodium PIC were involved in motoneuron firing because nimodipine only partly reduced the reflex and there remained very slow firing mediated by the calcium PIC.