抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Fundamentals of Plasmonics.- Electromagnetics of Metals.- Surface Plasmon Polaritons at Metal / Insulator Interfaces.- Excitation of Surface Plasmon Polaritons at Planar Interfaces.- Imaging Surface Plasmon Polariton Propagation.- Localized Surface Plasmons.- Electromagnetic Surface Modes at Low Frequencies.- Applications.- Plasmon Waveguides.- Transmission of Radiation Through Apertures and Films.- Enhancement of Emissive Processes and Nonlinearities.- Spectroscopy and Sensing.- Metamaterials and Imaging with Surface Plasmon Polaritons.- Concluding Remarks.

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Plasmonics: Fundamentals and Applications

A comprehensive review of spatiotemporal pattern formation in systems driven away from equilibrium is presented, with emphasis on comparisons between theory and quantitative experiments. Examples include patterns in hydrodynamic systems such as thermal convection in pure fluids and binary mixtures, Taylor-Couette flow, parametric-wave instabilities, as well as patterns in solidification fronts, nonlinear optics, oscillatory chemical reactions and excitable biological media. The theoretical starting point is usually a set of deterministic equations of motion, typically in the form of nonlinear partial differential equations. These are sometimes supplemented by stochastic terms representing thermal or instrumental noise, but for macroscopic systems and carefully designed experiments the stochastic forces are often negligible. An aim of theory is to describe solutions of the deterministic equations that are likely to be reached starting from typical initial conditions and to persist at long times. A unified description is developed, based on the linear instabilities of a homogeneous state, which leads naturally to a classification of patterns in terms of the characteristic wave vector q0 and frequency ω0 of the instability. Type Is systems (ω0=0, q0≠0) are stationary in time and periodic in space; type IIIo systems (ω0≠0, q0=0) are periodic in time and uniform in space; and type Io systems (ω0≠0, q0≠0) are periodic in both space and time. Near a continuous (or supercritical) instability, the dynamics may be accurately described via "amplitude equations," whose form is universal for each type of instability. The specifics of each system enter only through the nonuniversal coefficients. Far from the instability threshold a different universal description known as the "phase equation" may be derived, but it is restricted to slow distortions of an ideal pattern. For many systems appropriate starting equations are either not known or too complicated to analyze conveniently. It is thus useful to introduce phenomenological order-parameter models, which lead to the correct amplitude equations near threshold, and which may be solved analytically or numerically in the nonlinear regime away from the instability. The above theoretical methods are useful in analyzing "real pattern effects" such as the influence of external boundaries, or the formation and dynamics of defects in ideal structures. An important element in nonequilibrium systems is the appearance of deterministic chaos. A greal deal is known about systems with a small number of degrees of freedom displaying "temporal chaos," where the structure of the phase space can be analyzed in detail. For spatially extended systems with many degrees of freedom, on the other hand, one is dealing with spatiotemporal chaos and appropriate methods of analysis need to be developed. In addition to the general features of nonequilibrium pattern formation discussed above, detailed reviews of theoretical and experimental work on many specific systems are presented. These include Rayleigh-Benard convection in a pure fluid, convection in binary-fluid mixtures, electrohydrodynamic convection in nematic liquid crystals, Taylor-Couette flow between rotating cylinders, parametric surface waves, patterns in certain open flow systems, oscillatory chemical reactions, static and dynamic patterns in biological media, crystallization fronts, and patterns in nonlinear optics. A concluding section summarizes what has and has not been accomplished, and attempts to assess the prospects for the future.

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Pattern formation outside of equilibrium

An introductory review of the central ideas in the modern theory of dynamic critical phenomena is followed by a more detailed account of recent developments in the field. The concepts of the conventional theory, mode-coupling, scaling, universality, and the renormalization group are introduced and are illustrated in the context of a simple example---the phase separation of a symmetric binary fluid. The renormalization group is then developed in some detail, and applied to a variety of systems. The main dynamic universality classes are identified and characterized. It is found that the mode-coupling and renormalization group theories successfully explain available experimental data at the critical point of pure fluids, and binary mixtures, and at many magnetic phase transitions, but that a number of discrepancies exist with data at the superfluid transition of $^{4}\mathrm{He}$.

Theory of Dynamic Critical Phenomena

Recent research activities on the linear magnetoelectric (ME) effect?induction of magnetization by an electric field or of polarization by a magnetic field?are reviewed. Beginning with a brief summary of the history of the ME effect since its prediction in 1894, the paper focuses on the present revival of the effect. Two major sources for 'large' ME effects are identified. (i) In composite materials the ME effect is generated as a product property of a magnetostrictive and a piezoelectric compound. A linear ME polarization is induced by a weak ac magnetic field oscillating in the presence of a strong dc bias field. The ME effect is large if the ME coefficient coupling the magnetic and electric fields is large. Experiments on sintered granular composites and on laminated layers of the constituents as well as theories on the interaction between the constituents are described. In the vicinity of electromechanical resonances a ME voltage coefficient of up to 90?V?cm?1?Oe?1 is achieved, which exceeds the ME response of single-phase compounds by 3?5 orders of magnitude. Microwave devices, sensors, transducers and heterogeneous read/write devices are among the suggested technical implementations of the composite ME effect. (ii) In multiferroics the internal magnetic and/or electric fields are enhanced by the presence of multiple long-range ordering. The ME effect is strong enough to trigger magnetic or electrical phase transitions. ME effects in multiferroics are thus 'large' if the corresponding contribution to the free energy is large. Clamped ME switching of electrical and magnetic domains, ferroelectric reorientation induced by applied magnetic fields and induction of ferromagnetic ordering in applied electric fields were observed. Mechanisms favouring multiferroicity are summarized, and multiferroics in reduced dimensions are discussed. In addition to composites and multiferroics, novel and exotic manifestations of ME behaviour are investigated. This includes (i) optical second harmonic generation as a tool to study magnetic, electrical and ME properties in one setup and with access to domain structures; (ii) ME effects in colossal magnetoresistive manganites, superconductors and phosphates of the LiMPO4 type; (iii) the concept of the toroidal moment as manifestation of a ME dipole moment; (iv) pronounced ME effects in photonic crystals with a possibility of electromagnetic unidirectionality. The review concludes with a summary and an outlook to the future development of magnetoelectrics research.

https://iopscience.iop.org/article/10.1088/0022-3727/38/8/R01/pdf

Revival of the Magnetoelectric Effect

We make a step towards quantum nanoplasmonics: surface plasmon fields of a nanosystem are quantized and their stimulated emission is considered. We introduce a quantum generator for surface plasmon quanta and consider the phenomenon of surface plasmon amplification by stimulated emission of radiation (spaser). Spaser generates temporally coherent high-intensity fields of selected surface plasmon modes that can be strongly localized on the nanoscale, including dark modes that do not couple to far-zone electromagnetic fields. Applications and related phenomena are discussed.

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Surface plasmon amplification by stimulated emission of radiation: quantum generation of coherent surface plasmons in nanosystems.

As an efficient nanolens, we propose a self-similar linear chain of several metal nanospheres with progressively decreasing sizes and separations. To describe such systems, we develop the multipole spectral expansion method. Optically excited, such a nanolens develops the nanofocus ("hottest spot") in the gap between the smallest nanospheres, where the local fields are enhanced by orders of magnitude due to the multiplicative, cascade effect of its geometry and high Q factor of the surface plasmon resonance. The spectral maximum of the enhancement is in the near-ultraviolet region, shifting toward the red region as the separation between the spheres decreases. The proposed system can be used for nanooptical detection, Raman characterization, nonlinear spectroscopy, nanomanipulation of single molecules or nanoparticles, and other applications.

Self-similar chain of metal nanospheres as an efficient nanolens.

Publisher Summary This chapter discusses several composites or granular or porous materials that display inhomogeneity on a macroscopic scale. In such materials, there are small, yet much larger than atomic, regions exhibiting macroscopic homogeneity. Different regions may display quite different properties. The chapter discusses the dc and ac electrical properties of composite media including the basic theory and results for dc electrical properties. It also presents a discussion of the effective-medium approximation, electrostatic resonances, exact bounds, and analytical properties and describes a number of static physical properties of composites. These properties include electrical conductivity and dielectric behavior near a percolation threshold, magnetotransport, thermoelectricity, superconductivity, and duality in two-dimensional composites. Finally, the chapter discusses the nonlinear properties and flicker noise in composites.

Physical Properties of Macroscopically Inhomogeneous Media

From a partial-differential eigenproblem, without use of dipole approximation, we show that the eigenmodes (surface plasmons) of disordered nanosystems (modeled as random planar composites) are not universally Anderson localized, but can have properties of both localized and delocalized states simultaneously. Their topology is determined by separate small-scale "hot spots" that are distributed and coherent over a length that may be comparable to the total size of the system. Coherence lengths and oscillator strengths vary by orders of magnitude from mode to mode at nearby frequencies. The existence of dark vs luminous eigenmodes is established and attributed to the effect of charge- and parity-conservation laws. Possible applications are discussed.

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Localization versus delocalization of surface plasmons in nanosystems: can one state have both characteristics?

The behavior of the effective bulk conductivity ${\ensuremath{\sigma}}_{e}$ and of the effective bulk dielectric constant ${\ensuremath{\epsilon}}_{e}$ of a heterogeneous mixture of a conducting phase and an insulating dielectric phase is analyzed in the vicinity of the percolation threshold. Exact considerations of a general nature lead to the conclusion that ${\ensuremath{\epsilon}}_{e}$ diverges as the conductivity threshold is approached from either side. The introduction of a homogeneity or scaling hypothesis leads to relations between the critical behavior of ${\ensuremath{\sigma}}_{e}$ and ${\ensuremath{\epsilon}}_{e}$.

David J. Bergman

Papers

Surface plasmon amplification by stimulated emission of radiation: quantum generation of coherent surface plasmons in nanosystems.

Self-similar chain of metal nanospheres as an efficient nanolens.

Physical Properties of Macroscopically Inhomogeneous Media

Localization versus delocalization of surface plasmons in nanosystems: can one state have both characteristics?

Critical Behavior of the Complex Dielectric Constant near the Percolation Threshold of a Heterogeneous Material