David L. Braff

TL;DR: This paper will attempt to confirm the conclusions from a previous review that certain neurocognitive domains (secondary verbal memory, immediate memory, executive functioning as measured by card sorting, and vigilance) are associated with functional outcome.

TL;DR: A review of the literature on prepulse inhibition (PPI) in humans can be found in this article, where a relatively weak sensory event (the prepulse) is presented 30-500 ms before a strong startle-inducing stimulus, and reduces the magnitude of the startle response.

TL;DR: While the PPI model based on the effects of direct DA agonists is the most well-validated for the identification of known antipsychotic drugs, the isolation rearing model also appears to be sensitive to both typical and atypical antipsychotics, and the 5-HT P PI model is less generally sensitive to antippsychotic medications, but can provide insight into the contribution of serotonergic systems to the actions of newer antipsychosis that act upon multiple receptors.

TL;DR: Human and animal model studies of sensorimotor gating allow investigators to comment on the spatial and temporal mapping of neurons, trait and state deficits, and vulnerability factors in the schizophrenic spectrum of disorders.

TL;DR: When 20 normal subjects were compared to 12 schizophrenic subjects, significant differences in eyeblink response were found for blink amplitude and latency in the 60 msec prestimulus condition, which is consistent with information processing “overload” theories of sensory overstimulation in schizophrenia.