An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

Analyte Monitoring Device And Methods Of Use

An object is to provide a semiconductor device of which a manufacturing process is not complicated and by which cost can be suppressed, by forming a thin film transistor using an oxide semiconductor film typified by zinc oxide, and a manufacturing method thereof. For the semiconductor device, a gate electrode is formed over a substrate; a gate insulating film is formed covering the gate electrode; an oxide semiconductor film is formed over the gate insulating film; and a first conductive film and a second conductive film are formed over the oxide semiconductor film. The oxide semiconductor film has at least a crystallized region in a channel region.

Semiconductor device, and manufacturing method thereof

A disposable loading unit is disclosed for use in conjunction with a surgical stapling apparatus configured to sequentially apply a plurality of surgical fasteners to body tissue. The apparatus includes an actuation assembly for effectuating a fastener applying operation, and a housing for receiving and releasably supporting the disposable loading unit. The disposable loading unit includes a staple cartridge body having a longitudinal pathway extending therethrough and a plurality of spaced apart retention slots defined therein each supporting a respective surgical fastener, a plurality of fastener ejection members disposed adjacent the plurality of spaced apart retention slots and communicating with the longitudinal pathway, and an actuator supported within the staple cartridge body and configured to engage the actuation assembly of the apparatus and translate through the longitudinal pathway to contact the fastener ejection members and thereby sequentially eject the surgical fasteners from their respective retention slots.

Disposable loading unit for surgical stapler

The development of a robust method for integrating high-performance semiconductors on flexible plastics could enable exciting avenues in fundamental research and novel applications. One area of vital relevance is chemical and biological sensing, which if implemented on biocompatible substrates, could yield breakthroughs in implantable or wearable monitoring systems. Semiconducting nanowires (and nanotubes) are particularly sensitive chemical sensors because of their high surface-to-volume ratios. Here, we present a scalable and parallel process for transferring hundreds of pre-aligned silicon nanowires onto plastic to yield highly ordered films for low-power sensor chips. The nanowires are excellent field-effect transistors, and, as sensors, exhibit parts-per-billion sensitivity to NO2, a hazardous pollutant. We also use SiO2 surface chemistries to construct a ‘nano-electronic nose’ library, which can distinguish acetone and hexane vapours via distributed responses. The excellent sensing performance coupled with bendable plastic could open up opportunities in portable, wearable or even implantable sensors.

Highly ordered nanowire arrays on plastic substrates for ultrasensitive flexible chemical sensors

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Transcutaneous analyte sensor

In vivo evaluation of an electroenzymatic glucose sensor implanted in subcutaneous tissue.

A glucose-oxidase-based electroenzymatic glucose sensor has been developed using thin-/thick-film processing techniques. We believe that this processing scheme will overcome a major impediment to the successful movement of the devices from the research laboratory to the marketplace by removing the difficulty of fabricating large numbers of reproducible and economical sensors. Several hundred sensors have been fabricated and tested in vitro. The sensors respond linearly to glucose, are stable for 72 h, are oxygen independent and have a 90 s response time. The sensors have also responded appropriately during preliminary glucose tolerance tests performed in rabbits.

An electroenzymatic glucose sensor fabricated on a flexible substrate

A biocompatible thin film electrical component is configured for use in a human body or other ionic liquid environment. A polyimide substrate is bonded to a glass carrier plate sized for handling by automatic equipment and a multiple-layer metal conductor is deposited on the substrate and patterned to define an electrical circuit or biosensor. The polyimide and the glass establish a bond therebetween that withstands handling yet is broken using biocompatible releasing agents and techniques. The polyimide substrate and glass carrier plate preferably have similar thermal expansion properties to reduce the likelihood of fracture and delamination problems during release of the substrate from the carrier plate. An insulation layer covers the metal conductor and, in one embodiment, is made of a polyimide having a cure temperature lower than the temperature at which interdiffusion occurs in the metal layers in the conductor.

Thin film electrical component

Method of making a thin film electrical component

We present a method for fabricating electroenzymatic glucose sensors. The general approach i s to utilize thin- and thick-film deposition techniques similar to those used in the semiconductor processing industry. The sensors are fabricated in lots of 130, with the goal of a cheiving r eproducible s ensor performance and economical fabrication costs, using processes that can be readily up-scaled for manufacturing large numbers of sensors. The sensors are formed on a flexible substrate to provide less irritation and longer, more reliable operation when placed in vivo. Sensor operation has been characterized in vitro, and sensor performance has been found to meet

David Lipson

Papers

In vivo evaluation of an electroenzymatic glucose sensor implanted in subcutaneous tissue.

An electroenzymatic glucose sensor fabricated on a flexible substrate

Thin film electrical component

Method of making a thin film electrical component

Microfabrication Of Reproducible, Economical, Electroenzymatic Glucose Sensors