D
David McCarthy
Researcher at University College London
Publications - 22
Citations - 3094
David McCarthy is an academic researcher from University College London. The author has contributed to research in topics: Liposome & Gene delivery. The author has an hindex of 17, co-authored 22 publications receiving 2930 citations. Previous affiliations of David McCarthy include University of London.
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Journal ArticleDOI
Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery
Davide Pantarotto,Davide Pantarotto,Ravi Singh,David McCarthy,Mathieu Erhardt,Jean-Paul Briand,Maurizio Prato,Kostas Kostarelos,Alberto Bianco +8 more
TL;DR: Transmission electron microscopy analysis was performed at the microscopy facility of the Institute of Biomedical Problems and was cofinanced by CNRS, R=gion Alsace, Louis Pasteur University, and the Association de la Recherche pour le Cancer.
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Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors.
Ravi Singh,Davide Pantarotto,David McCarthy,Olivier Chaloin,Johan Hoebeke,Charalambos D. Partidos,Jean Paul Briand,Maurizio Prato,Alberto Bianco,Kostas Kostarelos +9 more
TL;DR: The results indicate that all three types of cationic carbon nanotubes are able to condense DNA to varying degrees, indicating that both nanotube surface area and charge density are critical parameters that determine the interaction and electrostatic complex formation between f-CNTs with DNA.
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Multiwalled carbon nanotube–doxorubicin supramolecular complexes for cancer therapeutics
Hanene Ali-Boucetta,Khuloud T. Al-Jamal,David McCarthy,Maurizio Prato,Alberto Bianco,Kostas Kostarelos +5 more
TL;DR: In this paper, multiwalled carbon nanotube aqueous dispersions using block copolymers are able to form supramolecular complexes with the aromatic chromophore and anticancer agent doxorubicin via pi-pi stacking and enhance its cytotoxic activity.
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Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration
TL;DR: Histological and chemical analysis proved the presence of titanium dioxide particles in all the major tissues of the gut associated lymphoid tissue (GALT), and demonstrated that 500 nm tianium dioxide particles were translocated to systemic organs such as the liver and the spleen.
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Nanosphere and microsphere uptake via Peyer's patches: observation of the rate of uptake in the rat after a single oral dose
TL;DR: Polystyrene latex particles of diameter 50 nm, 500 nm and 1 μm were fed by oral gavage as a single dose to female Sprague-Dawley rats at intervals following administration, and the uptake and movement of the particles to be monitored.