D
David R. Pimentel
Researcher at Boston University
Publications - 74
Citations - 9131
David R. Pimentel is an academic researcher from Boston University. The author has contributed to research in topics: Oxidative stress & Myocyte. The author has an hindex of 44, co-authored 72 publications receiving 8460 citations. Previous affiliations of David R. Pimentel include Boston Medical Center & Boston University Medical Campus.
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Journal ArticleDOI
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2—dependent mechanisms
Rei Shibata,Kaori Sato,David R. Pimentel,Yukihiro Takemura,Shinji Kihara,Koji Ohashi,Tohru Funahashi,Noriyuki Ouchi,Kenneth Walsh +8 more
TL;DR: It is suggested that adiponectin protects the heart from ischemia-reperfusion injury through both AMPK- and COX-2–dependent mechanisms.
Journal ArticleDOI
Norepinephrine Stimulates Apoptosis in Adult Rat Ventricular Myocytes by Activation of the β-Adrenergic Pathway
TL;DR: NE, acting via the ss-adrenergic pathway, stimulates apoptosis in adult rat cardiac myocytes in vitro and requires calcium entry via voltage-dependent calcium channels, which may contribute to the progression of myocardial failure.
Journal ArticleDOI
Adiponectin-mediated modulation of hypertrophic signals in the heart.
Rei Shibata,Noriyuki Ouchi,Masahiro Ito,Shinji Kihara,Ichiro Shiojima,David R. Pimentel,Masahiro Kumada,Kaori Sato,Stephan Schiekofer,Koji Ohashi,Tohru Funahashi,Wilson S. Colucci,Kenneth Walsh +12 more
TL;DR: It is found that pressure overload in adiponectin-deficient mice resulted in enhanced concentric cardiac hypertrophy and increased mortality that was associated with increased extracellular signal-regulatedKinase (ERK) and diminished AMP-activated protein kinase (AMPK) signaling in the myocardium.
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S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide
Takeshi Adachi,Robert M. Weisbrod,David R. Pimentel,Jia Ying,Victor S. Sharov,Christian Schöneich,Richard A. Cohen +6 more
TL;DR: In this paper, it was shown that NO-derived peroxynitrite (ONOO) directly increases SERCA activity by S-glutathiolation and that this modification of SERCA is blocked by irreversible oxidation of the relevant cysteine thiols during atherosclerosis.
Journal ArticleDOI
Role of Oxidative Stress in Myocardial Hypertrophy and Failure
Douglas B. Sawyer,Deborah A. Siwik,Lei Xiao,David R. Pimentel,Krishna Singh,Wilson S. Colucci +5 more
TL;DR: Increasing evidence from experimental models of on the nuclear genome but localizes to mitochondria via a mitochondrial targeting sequence, heart failure supports the concept that there is increased oxidative stress in the failing heart, and makes up >70% of the SOD activity in the heart and >90% the activity in cardiac myocytes.