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Shinji Kihara
Researcher at Osaka University
Publications - 210
Citations - 49287
Shinji Kihara is an academic researcher from Osaka University. The author has contributed to research in topics: Adiponectin & Adipose tissue. The author has an hindex of 85, co-authored 206 publications receiving 47130 citations. Previous affiliations of Shinji Kihara include Otsuka Pharmaceutical.
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Journal ArticleDOI
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Yukio Arita,Shinji Kihara,Noriyuki Ouchi,Masahiko Takahashi,Kazuhisa Maeda,Jun-ichiro Miyagawa,Kikuko Hotta,Iichiro Shimomura,Tadashi Nakamura,Koji Miyaoka,Hiroshi Kuriyama,Makoto Nishida,Shizuya Yamashita,Kosaku Okubo,Kenji Matsubara,Masahiro Muraguchi,Yasuichi Ohmoto,Tohru Funahashi,Yuji Matsuzawa +18 more
TL;DR: Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
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Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Kikuko Hotta,Tohru Funahashi,Yukio Arita,Masahiko Takahashi,Morihiro Matsuda,Yoshihisa Okamoto,Hiromi Iwahashi,Hiroshi Kuriyama,Noriyuki Ouchi,Kazuhisa Maeda,Makoto Nishida,Shinji Kihara,Naohiko Sakai,Tadahisa Nakajima,Kyoichi Hasegawa,Masahiro Muraguchi,Yasukazu Ohmoto,Tadashi Nakamura,Shizuya Yamashita,Toshiaki Hanafusa,Yuji Matsuzawa +20 more
TL;DR: Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects.
Journal ArticleDOI
Novel Modulator for Endothelial Adhesion Molecules: Adipocyte-Derived Plasma Protein Adiponectin
Noriyuki Ouchi,Shinji Kihara,Yukio Arita,Kazuhisa Maeda,Hiroshi Kuriyama,Yoshihisa Okamoto,Kikuko Hotta,Makoto Nishida,Masahiko Takahashi,Tadashi Nakamura,Shizuya Yamashita,Tohru Funahashi,Yuji Matsuzawa +12 more
TL;DR: Observations suggest that adiponectin modulates endothelial inflammatory response and that the measurement of plasma adiponECTin levels may be helpful in assessment of CAD risk.
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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
Norikazu Maeda,Iichiro Shimomura,Ken Kishida,Hitoshi Nishizawa,Morihiro Matsuda,Hiroyuki Nagaretani,Naoki Furuyama,Hidehiko Kondo,Masahiko Takahashi,Yukio Arita,Ryutaro Komuro,Noriyuki Ouchi,Shinji Kihara,Yoshihiro Tochino,Keiichi Okutomi,Masato Horie,Satoshi Takeda,Toshifumi Aoyama,Tohru Funahashi,Yuji Matsuzawa +19 more
TL;DR: The results indicate that adiponectin/ACRP30 deficiency and high TNF-α levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance.
Journal ArticleDOI
Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway
Noriyuki Ouchi,Shinji Kihara,Yukio Arita,Yoshihisa Okamoto,Kazuhisa Maeda,Hiroshi Kuriyama,Kikuko Hotta,Makoto Nishida,Masahiko Takahashi,Masahiro Muraguchi,Yasukazu Ohmoto,Tadashi Nakamura,Shizuya Yamashita,Tohru Funahashi,Yuji Matsuzawa +14 more
TL;DR: The possibility that adiponectin, which is naturally present in the blood stream, modulates the inflammatory response of endothelial cells through cross talk between cAMP-PKA and NF-&kgr;B signaling pathways is raised.