Showing papers by "David R. Rubinow published in 1992"
TL;DR: Depressed patients were significantly impaired in the recognition of affect in the facial, but not verbal, expressions, and the relevance of the observed perceptual deficit in depressed patients to the pathophysiology and symptomatology of depression is discussed.
273 citations
Journal Article•
TL;DR: Findings indicate that panic disorder patients have significantly blunted GH responses to clonidine, yohimbine, growth-hormone releasing factor, and caffeine compared to normal control subjects, providing support for a hyporesponsive hypothalamic-GH system in panic disorder.
53 citations
TL;DR: A 30-year-old married mother of four was referred to the National Institute of Mental Health for a cyclic mood disorder because she became profoundly irritable around others and demonstrated anger, impatience, "meanness," overreactivity, and verbal outbursts.
Abstract: CASE PRESENTATION A 30-year-old married mother of four was referred to the National Institute of Mental Health for a cyclic mood disorder. She observed that over the preceding 7 years she experienced mood and somatic symptoms seemingly related to her menstrual cycle. Approximately 9 days before her menses, she would become sad and cry, want to be alone, and experience sensitivity to rejection, guilt, self-criticism, and occasional suicidal ideation. These symptoms were not responsive to expressed concern from others. Rather, she attempted to isolate herself because she became profoundly irritable around others and demonstrated anger, impatience, "meanness," overreactivity, and verbal outbursts. Her verbal loss of control caused problems at work and in her relationships with her family. Other symptoms included a decrease in her general level of interest and energy, an inability to initiate activities or to experience pleasure, fatigue, disturbed sleep, distractibility, indecisiveness, and increased appetite and food intake
37 citations
TL;DR: The relevant studies examining the association between endocrine changes and the premenstrual syndrome are reviewed, along with the currently popular hypotheses of the etiology of this distressing and prevalent disorder.
Abstract: The premenstrual syndrome is a constellation of mood, behavioral, and somatic symptoms that occurs in a cyclical pattern linked to the reproductive cycle in women. Most prevalent hypotheses associate the etiology of the disorder to changes in “menstrual cycle” hormones. Recent findings, however, question the validity of this simple hypothesis, and point toward a considerably more complex etiology. The relevant studies examining the association between endocrine changes and the premenstrual syndrome are reviewed in this paper, along with the currently popular hypotheses of the etiology of this distressing and prevalent disorder.
30 citations