Selectivity in propene polymerization with metallocene catalysts.

Precise control of polyolefin stereochemistry using single-site metal catalysts.

Michael addition reactions in macromolecular design for emerging technologies

Although the concept of using pharmacologically active macromolecular compounds as drugs is still regarded with much skepticism for both theoretical and practical reasons, interest in this field has grown in recent years because of the opportunity to take advantage of the specific properties of polymeric materials. For low molecular weight drugs, changes in structure often lead to a loss of specific activity. On the other hand, the properties of macromolecular drugs depend on the structure of the polymer used and this can be varied over a wide range by the incorporation of comonomer units, by the application of polymer-analogous reactions, or by related structural changes. A new model is presented for pharmacologically active polymers which incorporates the possibility for continuous variation in (a) solubility and toxicity, (b) fixation and removal of active material, and (c) body distribution. Using the new model as a guide, examples of the synthesis and study of the biological activity of various macromolecular drugs are presented in order to emphasize the importance of this cooperative effort between polymer research and therapeutic problems.

Structure and properties of pharmacologically active polymers

Effect of the Nature of Metallocene Complexes of Group IV Metals on Their Performance in Catalytic Ethylene and Propylene Polymerization

The Reaction of Cobalt Hydrotetracarbonyl with Olefins

Bis-(cyclopentadienyl)-titanium dichloride —alkylaluminum complexls as catalysts for the polymerization of ethylene

Hydrogenation of unsaturated hydrocarbons

Soluble Catalysts for the Hydrogenation of Olefins

Synthesis of Poly-β-alanine from Acrylamide. A Novel Synthesis of β-Alanine1

David S. Breslow

Papers

The Reaction of Cobalt Hydrotetracarbonyl with Olefins

Bis-(cyclopentadienyl)-titanium dichloride —alkylaluminum complexls as catalysts for the polymerization of ethylene

Hydrogenation of unsaturated hydrocarbons

Soluble Catalysts for the Hydrogenation of Olefins

Synthesis of Poly-β-alanine from Acrylamide. A Novel Synthesis of β-Alanine1