D
David Saperstein
Researcher at University of Kansas
Publications - 71
Citations - 3095
David Saperstein is an academic researcher from University of Kansas. The author has contributed to research in topics: Polyneuropathy & Myasthenia gravis. The author has an hindex of 23, co-authored 68 publications receiving 2828 citations. Previous affiliations of David Saperstein include University of Texas Southwestern Medical Center & Wilford Hall Medical Center.
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Journal ArticleDOI
Interferon‐α/β–mediated innate immune mechanisms in dermatomyositis
Steven A. Greenberg,Jack L. Pinkus,Geraldine S. Pinkus,Travis Burleson,Despina Sanoudou,Rabi Tawil,Richard J. Barohn,David Saperstein,Hannah R. Briemberg,Maria Ericsson,Peter J. Park,Peter J. Park,Anthony A. Amato +12 more
TL;DR: An innate immune response characterized by plasmacytoid dendritic cell infiltration and interferon‐α/β inducible gene and protein expression may be an important part of the pathogenesis of dermatomyositis, as it appears to be in systemic lupus erythematosus.
Journal ArticleDOI
Clinical spectrum of chronic acquired demyelinating polyneuropathies.
TL;DR: A clinical scheme for approaching the chronic acquired demyelinating polyneuropathies that leads to a rational use of supportive laboratory studies and treatment options is described and new diagnostic criteria for CIDP are proposed that more accurately reflect current clinical practice.
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Distal acquired demyelinating symmetric neuropathy.
TL;DR: Distinguishing acquired demyelinating neuropathies by phenotype can often predict the presence of IgM kappa M-proteins, anti-MAG antibodies, and responses to immunomodulating therapy.
Journal ArticleDOI
Multifocal acquired demyelinating sensory and motor neuropathy: the Lewis-Sumner syndrome.
David Saperstein,Anthony A. Amato,Gil I. Wolfe,Jonathan S. Katz,Sharon P. Nations,Carlayne E. Jackson,Wilson W. Bryan,Dennis K. Burns,Richard J. Barohn +8 more
TL;DR: Eleven patients with multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy are reported, defined clinically by a multifocal pattern of motor and sensory loss, with nerve conduction studies showing conduction block and other features of demYelination.
Journal ArticleDOI
Chronic Cryptogenic Sensory Polyneuropathy: Clinical and Laboratory Characteristics
Gil I. Wolfe,Noel S. Baker,Anthony A. Amato,Carlayne E. Jackson,Sharon P. Nations,David Saperstein,Choon H. Cha,Jonathan S. Katz,Wilson W. Bryan,Richard J. Barohn +9 more
TL;DR: Cryptogenic sensory polyneuropathy is a common, slowly progressive neuropathy that begins in late adulthood and causes limited motor impairment and management should focus on rational pharmacotherapy of neuropathic pain combined with reassurance of CSPN's benign clinical course.