D
David Sedmera
Researcher at Academy of Sciences of the Czech Republic
Publications - 150
Citations - 5578
David Sedmera is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Ventricle & Electrical conduction system of the heart. The author has an hindex of 38, co-authored 139 publications receiving 5016 citations. Previous affiliations of David Sedmera include First Faculty of Medicine, Charles University in Prague & University of Lausanne.
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Journal ArticleDOI
Developmental patterning of the myocardium.
David Sedmera,David Sedmera,Tomas Pexieder,Mauricette Vuillemin,Robert P. Thompson,Robert H. Anderson +5 more
TL;DR: It is concluded that experimental studies uncovering the rules of myocardial assembly are relevant for the full understanding of development of the human heart.
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Structure and function of the developing zebrafish heart.
TL;DR: A longitudinal study to define the cardiac morphology and physiology of the developing zebrafish, finding that until maturity, the atrium showed extensive pectinate muscles, and the atrial wall increased to two to three cell layers, while the extent and complexity in trabeculation continued.
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Remodeling of chick embryonic ventricular myoarchitecture under experimentally changed loading conditions
TL;DR: Adult myocardium adapts to changing functional demands by hyper‐ or hypotrophy while the developing heart reacts by hyper- or hypoplasia, and chick embryonic hearts subjected to mechanically altered loading to study its influence upon ventricular myoarchitecture.
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Developmental anatomy of the heart: a tale of mice and man
Andy Wessels,David Sedmera +1 more
TL;DR: The analysis of mouse mutants with impaired septation will provide valuable information on cellular mechanisms involved in valvuloseptal morphogenesis (a process often disrupted in congenital heart disease), while the study of embryonic lethal mouse mutants that present with lack of compaction of ventricular trabeculae will ultimately provide clues on the etiology of this abnormality in humans.
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Hemodynamics Is a Key Epigenetic Factor in Development of the Cardiac Conduction System
Maria Reckova,Carlin Rosengarten,Angela deAlmeida,Chiffvon P. Stanley,Andy Wessels,Robert G. Gourdie,Robert P. Thompson,David Sedmera +7 more
TL;DR: A critical role for biophysical factors in differentiation of specialized cardiac tissues is indicated and a new model for studies of the molecular mechanisms involved in induction and patterning of the HPS in vivo is provided.