R
Robert P. Thompson
Researcher at Medical University of South Carolina
Publications - 75
Citations - 4640
Robert P. Thompson is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Heart development & Electrical conduction system of the heart. The author has an hindex of 37, co-authored 74 publications receiving 4463 citations. Previous affiliations of Robert P. Thompson include National Institutes of Health.
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Journal ArticleDOI
Developmental patterning of the myocardium.
David Sedmera,David Sedmera,Tomas Pexieder,Mauricette Vuillemin,Robert P. Thompson,Robert H. Anderson +5 more
TL;DR: It is concluded that experimental studies uncovering the rules of myocardial assembly are relevant for the full understanding of development of the human heart.
Journal ArticleDOI
Dissociated Spatial Patterning of Gap Junctions and Cell Adhesion Junctions During Postnatal Differentiation of Ventricular Myocardium
Brigitt D. Angst,Laeeq U.R. Khan,Nicholas J. Severs,Kate Whitely,Stephen Rothery,Robert P. Thompson,Anthony I. Magee,Robert G. Gourdie +7 more
TL;DR: It is concluded that this progressive change in the organization and pattern of association between gap junctions and cell adhesion junctions is likely to be an important factor in maturation of electromechanical function within the mammalian heart.
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Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system.
TL;DR: It is reported that a subset of clonally related myocytes differentiates into conductile Purkinje fibers, invariably in close spatial association with forming coronary arterial blood vessels.
Journal ArticleDOI
Hemodynamics Is a Key Epigenetic Factor in Development of the Cardiac Conduction System
Maria Reckova,Carlin Rosengarten,Angela deAlmeida,Chiffvon P. Stanley,Andy Wessels,Robert G. Gourdie,Robert P. Thompson,David Sedmera +7 more
TL;DR: A critical role for biophysical factors in differentiation of specialized cardiac tissues is indicated and a new model for studies of the molecular mechanisms involved in induction and patterning of the HPS in vivo is provided.
Journal ArticleDOI
Functional and morphological evidence for a ventricular conduction system in zebrafish and Xenopus hearts
David Sedmera,Maria Reckova,Maria Reckova,Maria Reckova,Angela deAlmeida,Angela deAlmeida,Angela deAlmeida,Martina Sedmerova,Martin Biermann,Jiri Volejnik,Alexandre Sarre,Eric Raddatz,Robert A. McCarthy,Robert G. Gourdie,Robert P. Thompson +14 more
TL;DR: It is concluded that single ventricular hearts of zebrafish and Xenopus are able to achieve the apex-to-base ventricular activation pattern observed in higher vertebrates in the apparent absence of differentiated conduction fascicles, suggesting that the ventricular trabeculae serve as a functional equivalent of the His-Purkinje system.