Showing papers by "David W. Johnson published in 1967"

Studies of Venereal Disease: I. Probenecid-Procaine Penicillin G Combination and Tetracycline Hydrochloride in the Treatment of Penicillin-Resistant Gonorrhea in Men

Abstract: Treatment of gonorrhea in men with a single intramuscular dose of 2,400,000 units of procaine penicillin G, recommended by the US Public Health Service and the armed forces in 1965, continues to result in 20% to 30% treatment failures among military personnel in the Far East. In studies of confined populations aboard air-craft carriers, 63 men with gonorrhea received 2,400,000 units of procaine penicillin G with 18 (29%) treatment failures; 58 men received 2,400,000 units procaine penicillin Gplus probenecidorally, with only one failure. Resistance to 0.06 units of penicillin per milliliter of medium was noted in 26 of 41 (63%) and 57 of 74 (77%)Neisseria gonorrhoeaeisolates from the respective groups. Thirty men received tetracycline hydrochloride orally, with no failures. In areas where treatment of gonorrhea with large parenteral doses of penicillin G is becoming less effective, adequate therapy is possible with probenecid plus penicillin or with tetracycline.

Studies of Venereal Disease: II. Observations on the Incidence, Etiology, and Treatment of the Postgonococcal Urethritis Syndrome

Abstract: Postgonococcal urethritis (PGU) occurred in nearly two thirds of men with gonorrhea acquired in the Far East who were "successfully" treated with 2,400,000 units of procaine penicillin G plus probenecid. PGU occurred less often after treatment of gonorrhea with tetracycline hydrochloride, and PGU itself responded to tetracycline, suggesting a microbial etiology for the condition. The syndrome was associated to a highly significant degree withMycoplasmainfection of the urethra, and occurred more often after infection with Neisseriagonorrhoeaeof lessened penicillin sensitivity. The high incidence of the syndrome, one of the most common infectious diseases among military personnel in the Far East, requires a reexamination of the traditional use of penicillin in the treatment of gonorrhea in men.

Studies of Venereal Disease: III. Double-Blind Comparison of Tetracycline Hydrochloride and Placebo in Treatment of Nongonococcal Urethritis

Abstract: Previous studies of the treatment of nongonococcal urethritis (NGU) have generally not been closely controlled, and have often produced conflicting results. In the present study, 96 men with NGU were treated with placebo or tetracycline hydrochloride while "confined" aboard an aircraft carrier at sea. A seven-day tetracycline regimen was more effective than a four-day tetracycline regimen or placebo in the short-term cure of NGU.