Institution
Naval Medical Center San Diego
Healthcare•San Diego, California, United States•
About: Naval Medical Center San Diego is a healthcare organization based out in San Diego, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 3446 authors who have published 3916 publications receiving 110653 citations. The organization is also known as: NMCSD & Bob Wilson Naval Hospital.
Topics: Population, Poison control, Health care, Vaccination, Medicine
Papers published on a yearly basis
Papers
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TL;DR: The routine use of combination therapy with fenofibrate and simvastatin to reduce cardiovascular risk in the majority of high-risk patients with type 2 diabetes does not support the routine use.
Abstract: Methods We randomly assigned 5518 patients with type 2 diabetes who were being treated with open-label simvastatin to receive either masked fenofibrate or placebo. The primary outcome was the first occurrence of nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes. The mean follow-up was 4.7 years. Results The annual rate of the primary outcome was 2.2% in the fenofibrate group and 2.4% in the placebo group (hazard ratio in the fenofibrate group, 0.92; 95% confidence interval [CI], 0.79 to 1.08; P = 0.32). There were also no significant differences between the two study groups with respect to any secondary outcome. Annual rates of death were 1.5% in the fenofibrate group and 1.6% in the placebo group (hazard ratio, 0.91; 95% CI, 0.75 to 1.10; P = 0.33). Prespecified subgroup analyses suggested heterogeneity in treatment effect according to sex, with a benefit for men and possible harm for women (P = 0.01 for interaction), and a possible interaction according to lipid subgroup, with a possible benefit for patients with both a high baseline triglyceride level and a low baseline level of high-density lipoprotein cholesterol (P = 0.057 for interaction). Conclusions The combination of fenofibrate and simvastatin did not reduce the rate of fatal cardiovascular events, nonfatal myocardial infarction, or nonfatal stroke, as compared with simvastatin alone. These results do not support the routine use of combination therapy with fenofibrate and simvastatin to reduce cardiovascular risk in the majority of high-risk patients with type 2 diabetes. (ClinicalTrials.gov number, NCT00000620.)
2,451 citations
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Centers for Disease Control and Prevention1, University of Cambridge2, National Institutes of Health3, Erasmus University Rotterdam4, Naval Medical Center San Diego5, Arizona State University6, Colorado Department of Public Health and Environment7, Oklahoma State Department of Health8, Wadsworth Center9, Ohio Department of Health10, South Carolina Department of Health and Environmental Control11, Dallas County12, Baylor College of Medicine13, San Diego State University14, Centra15, California Health and Human Services Agency16, Marshfield Clinic17, Michigan Department of Community Health18
TL;DR: The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period as mentioned in this paper.
Abstract: Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).
2,393 citations
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TL;DR: The Diabetes Distress Scale has a consistent, generalizable factor structure and good internal reliability and validity across four different clinical sites, and may serve as a valuable measure of diabetes-related emotional distress for use in research and clinical practice.
Abstract: OBJECTIVE —The purpose of this study was to describe the development of the Diabetes Distress Scale (DDS), a new instrument for the assessment of diabetes-related emotional distress, based on four independent patient samples. RESEARCH DESIGN AND METHODS —In consultation with patients and professionals from multiple disciplines, a preliminary scale of 28 items was developed, based a priori on four distress-related domains: emotional burden subscale, physician-related distress subscale, regimen-related distress subscale, and diabetes-related interpersonal distress. The new instrument was included in a larger battery of questionnaires used in diabetes studies at four diverse sites: waiting room at a primary care clinic ( n = 200), waiting room at a diabetes specialty clinic ( n = 179), a diabetes management study program ( n = 167), and an ongoing diabetes management program ( n = 158). RESULTS —Exploratory factor analyses revealed four factors consistent across sites (involving 17 of the 28 items) that matched the critical content domains identified earlier. The correlation between the 28-item and 17-item scales was very high ( r = 0.99). The mean correlation between the 17-item total score (DDS) and the four subscales was high ( r = 0.82), but the pattern of interscale correlations suggested that the subscales, although not totally independent, tapped into relatively different areas of diabetes-related distress. Internal reliability of the DDS and the four subscales was adequate (α > 0.87), and validity coefficients yielded significant linkages with the Center for Epidemiological Studies Depression Scale, meal planning, exercise, and total cholesterol. Insulin users evidenced the highest mean DDS total scores, whereas diet-controlled subjects displayed the lowest scores ( P CONCLUSIONS —The DDS has a consistent, generalizable factor structure and good internal reliability and validity across four different clinical sites. The new instrument may serve as a valuable measure of diabetes-related emotional distress for use in research and clinical practice.
1,094 citations
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TL;DR: HIV-related NP impairment was generally mild, especially in the medically asymptomatic stage of infection, and most often affected attention, speed of information processing, and learning efficiency; this pattern is consistent with earliest involvement of subcortical or frontostriatal brain systems.
Abstract: The present study examined neuropsychological (NP) functioning and associated medical, neurological, brain magnetic resonance imaging (MRI), and psychiatric findings in 389 nondemented males infected with Human Immunodeficiency Virus-Type 1 (HIV-1), and in 111 uninfected controls. Using a comprehensive NP test battery, we found increased rates of impairment at each successive stage of HIV infection. HIV-related NP impairment was generally mild, especially in the medically asymptomatic stage of infection, and most often affected attention, speed of information processing, and learning efficiency; this pattern is consistent with earliest involvement of subcortical or frontostriatal brain systems. NP impairment could not be explained on the bases of mood disturbance, recreational drug or alcohol use, or constitutional symptoms; by contrast, impairment in HIV-infected subjects was related to central brain atrophy on MRI, as well as to evidence of cellular immune activation and neurological abnormalities linked to the central nervous system. ( JINS , 1995, 1 , 231–251.)
642 citations
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TL;DR: The four-quadrant sum of amniotic fluid pockets (amniotic fluid index) was studied prospectively in 791 normal pregnancies and the values for each week were statistically distinct, indicating the need to reference amniotics fluid index measurements to week-specific normative tables for accurate interpretation.
518 citations
Authors
Showing all 3457 results
Name | H-index | Papers | Citations |
---|---|---|---|
William M. Pardridge | 116 | 551 | 47861 |
Igor Grant | 113 | 791 | 55147 |
Michael L. Blute | 112 | 527 | 45296 |
Constantine G. Lyketsos | 111 | 567 | 43932 |
Peter J. Park | 110 | 357 | 106149 |
Henry N. Ginsberg | 104 | 413 | 51009 |
Horst Zincke | 101 | 375 | 30818 |
Robert Peter Gale | 97 | 369 | 36058 |
Gary S. Francis | 97 | 411 | 53376 |
R. Rox Anderson | 96 | 486 | 37182 |
David B. Hoyt | 95 | 455 | 31309 |
Thomas A. Einhorn | 94 | 330 | 32850 |
Alan F. Hofmann | 94 | 435 | 31340 |
Paolo Pelosi | 93 | 852 | 37918 |
William F. Crowley | 92 | 304 | 29242 |