PURPOSE:To provide a new compound exhibiting durable hypotensive action and peripheral vessel relaxing action by the activation of calcium channel and useful as an agent for the treatment of hypertension CONSTITUTION:The compound of formula I (R is lower alkyl, cycloalkyl, etc; R is OH, lower alkoxy, etc; R is H or lower alkyl; R is H, OH, etc; R is lower alkyl, lower alkoxy, etc; R and R are lower alkyl or together form an alkylene), eg N-(trans-6-cyano-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1- benzopyran-4-yl)-N'-hydroxyacetamidine The compound of formula I can be produced by reacting a compound of formula II (R is H, OH, etc) with a compound of formula III (X is alkoxy or alkylthio) and reacting the resultant compound of formula IV with a reagent (eg cyanogen bromide, ethyl chloroformate and isocyanate)

得生山木

Papers

New benzopyran derivative

得生 山木

Papers

New benzopyran derivative

得生山木