The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.

1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3-Dioxygenase

The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.

Modulators of indoleamine 2,3-dioxygenase and methods of using the same

The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.

N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase

Compounds, salts thereof, and tautomers thereof are disclosed. Compositions that include the compounds are disclosed. Methods of making and using the compounds are also disclosed.

Novel antiviral compounds, compositions, and methods of use

The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.

Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor

A novel benzopyran derivative represented by general formula (I) and a pharmaceutically acceptable salt thereof, wherein each symbol is as defined in the specification. This compound is useful for treating hypertension, because it has a persistent hypotensive activity and a peripheral blood relaxing activity by activating a potassium channel, and also for treating cardiovascular diseases such as angina pectoris and heart failure, because it has a selective coronary blood stream increasing activity.

Novel benzopyran derivative

PURPOSE:To provide a new compound exhibiting durable hypotensive action and peripheral vessel relaxing action by the activation of calcium channel and useful as an agent for the treatment of hypertension CONSTITUTION:The compound of formula I (R is lower alkyl, cycloalkyl, etc; R is OH, lower alkoxy, etc; R is H or lower alkyl; R is H, OH, etc; R is lower alkyl, lower alkoxy, etc; R and R are lower alkyl or together form an alkylene), eg N-(trans-6-cyano-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1- benzopyran-4-yl)-N'-hydroxyacetamidine The compound of formula I can be produced by reacting a compound of formula II (R is H, OH, etc) with a compound of formula III (X is alkoxy or alkylthio) and reacting the resultant compound of formula IV with a reagent (eg cyanogen bromide, ethyl chloroformate and isocyanate)

Katoh Susumu

Papers

Novel benzopyran derivative

New benzopyran derivative