D
Debaprasad Parai
Researcher at Regional Medical Research Centre
Publications - 50
Citations - 447
Debaprasad Parai is an academic researcher from Regional Medical Research Centre. The author has contributed to research in topics: Medicine & Seroprevalence. The author has an hindex of 8, co-authored 30 publications receiving 191 citations. Previous affiliations of Debaprasad Parai include Government of India & L V Prasad Eye Institute.
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Andrographolide: antibacterial activity against common bacteria of human health concern and possible mechanism of action.
TL;DR: Andro showed potential antibacterial activity against most of the tested Gram-positive bacteria, and might be accounted as a promising lead for new antibacterial drug development.
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Effect of reserpine on Pseudomonas aeruginosa quorum sensing mediated virulence factors and biofilm formation.
Debaprasad Parai,Malabika Banerjee,Pia Dey,Arindam Chakraborty,Ekramul Islam,Samir Kumar Mukherjee +5 more
TL;DR: Analysis of molecular docking analysis for AHL synthase LasI and QS transcriptional regulators LasR/MvfR revealed a plausible molecular mechanisms of reserpine QS inhibition that may be useful in the development of new drugs against biofilm-related infections.
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Naringin sensitizes the antibiofilm effect of ciprofloxacin and tetracycline against Pseudomonas aeruginosa biofilm
TL;DR: Naringin potentiates the efficacy of both ciprofloxacin and tetracycline on P. aeruginosa biofilm in comparison to their solo treatment, suggesting on the possibility of its use in drug-herb combinations for managing biofilm-associated bacterial infections.
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Attenuation of Pseudomonas aeruginosa quorum sensing, virulence and biofilm formation by extracts of Andrographis paniculata.
Malabika Banerjee,Soumitra Moulick,Kunal Kumar Bhattacharya,Debaprasad Parai,Subrata Chattopadhyay,Samir Kumar Mukherjee +5 more
TL;DR: It is demonstrated that Andrographis paniculata extracts inhibit QS in P. aeruginosa and exhibit anti-inflammatory activities, therefore it represents itself as a prospective therapeutic agent against P.aerugInosa infection.
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Reserpine attenuates biofilm formation and virulence of Staphylococcus aureus.
TL;DR: Reserpine along with other commercial antibiotics could generate a hightened antibiofilm response and could also eradicate a good percentage of bacterial biofilm from a urinary catheter model, suggested reserpine as a good alternative entity to generate new improved therapeutic formulations.