Showing papers in "International Journal of Medical Microbiology in 2020"

TL;DR: The interaction between the parasite, the human host, and the colon microbiota or pathogenic microorganisms, which together give rise to intestinal amoebiasis are analyzed.

TL;DR: The identification of a novel Stx2 subtype, designated Stx1/Stx2k, in E. coli strains widely detected from diarrheal patients, animals, and raw meats in China over time is reported and highlights the extraordinary genomic plasticity of STEC strains.

TL;DR: Results suggest that GyrA was protected from oxidation in vivo in the allicin-tolerant Pf AR-1 background, rather than the PfAR-1 Gyr A subunit being intrinsically less susceptible to oxidation by allicIn than the Pratincole gyrase subunit.

TL;DR: It is revealed that the respective virulence gene inventories of the five genotypes corresponded with the time needed to kill 100 % of the infected bee larvae in in vivo infection assays.

TL;DR: The data revealed that sncRNAs (sR-2509025 and sR-989262) were enriched in OMVs, and reduced lipopolysaccharide or OMV-induced interleukin 8 (IL-8) secretion by cultured AGS cells are consistent with the hypothesis that H. pylori evades the host immune response.

TL;DR: In this review, relevant data regarding the possible mechanisms that can account for the effects of gut microbial metabolites mentioned above in carcinogenesis are summarized.

TL;DR: Naringin potentiates the efficacy of both ciprofloxacin and tetracycline on P. aeruginosa biofilm in comparison to their solo treatment, suggesting on the possibility of its use in drug-herb combinations for managing biofilm-associated bacterial infections.

TL;DR: Findings manifested that EO exerts antibacterial effect by multiple avenues and expands the understanding of the antibacterial mechanism, it has potential application value in food preservative and pharmaceutical industries.

TL;DR: LP3 had anti-inflammatory effects, with increased induction of regulatory T cells and type 2 helper T cells in splenocytes and restoration of goblet cells accompanied by suppression of proinflammatory cytokine expressions, suggesting that L. plantarum CBT LP3 can be used as a potent immunomodulator, which has significant implications for IBD treatment.

TL;DR: This review covers the existing evidence on the mutual dynamics of host GI mucus, the mucosal habitat and incoming acute and chronic pathogens during GI infections and explores the role of carbohydrates in diverse mucosal interaction, communication and competition processes.

TL;DR: It is demonstrated that Mtb requires ClpB to survive under stressful conditions and is necessary for the bacteria to persist in latency-like conditions such as prolonged hypoxia and nutrient-starvation, and it is concluded that ClPB is essential for Mtb to survive within macrophages.

TL;DR: This is the first report to demonstrate that the N-terminal domain of OprF is sufficiently immunogenic to protect against the two pathogens P. aeruginosa and A. baumannii.

TL;DR: Induction of mucosal and systemic immunity was investigated after intranasal immunization of BALB/c mice and it was indicated that comprise of B. abortus antigen-loaded CNs elicited the antigen-specific IgA with a Th2-polarized immune responses and combination of the highly immunogenic antigens elicit IgG specific to each type of antigen.

TL;DR: Data suggests that older mice maybe more susceptible to Lm infection due to an imbalance of Th cell responses with disproportionate and persistent anti-inflammatory responses, which may also exacerbate pathological responses during listeriosis.

TL;DR: It is demonstrated that mgrB alterations were the most common source of polymyxin-resistance in Brazilian clinical settings, and a novel 78-bp repeat sequence, encoding a MgrB protein with 26 amino acids duplicated in six isolates was identified.

TL;DR: Tests with subinhibitory concentrations of different antibiotics indicated that only SOS response-inducing antibiotics led to an increased loss of islands which was always associated with an increase in the bacterial subpopulations showing high integrase promoter activity, suggesting that island excision correlates with the expression of the cognate integrase.

TL;DR: Preparation of fungal DNA from human specimens is optimized by introduction of a bead beating step to the conventional DNA-preparation method without the necessity of a liquid nitrogen step.

TL;DR: The genomic relationship to elucidate the diversity and evolution of P. multocida is described for the first time, with results showing a flexible genome for hosting mobile genetic elements and therefore significant variation in gene content.

TL;DR: The proposed diagnostic application was drawn upon recent discoveries of patterns of Mtb clade-specific genetic polymorphisms associated with antibiotic resistance, and proved to be suitable for probabilistic prediction of drug resistance profiles of individual strains and large sequence data sets.

TL;DR: Insight is provided into the first tripartite type-I TA system and the role of MDR NorA in the persister cell formation of S. aureus is revealed.

TL;DR: The generation of a complete genome for ATCC 19606 using PacBio sequencing is reported and a genome-scale metabolic model (GSMM) iATCC19606v2 was constructed using the complete genome annotation, providing valuable tools for antimicrobial systems pharmacological investigations on A. baumannii.

TL;DR: NETs formation by Pseudomonas clinical isolates obtained from CF patients are evaluated and it is found that these induced NETs formation with globular or spread morphologies, of note, it was found that there is a trend by which the spread forms were induced mainly by isolate obtained from patients with severe disease, whereas, the globular morphologies were observed for isolate obtained from Patients with mild/moderate disease.

TL;DR: This study demonstrates that changes in transcription regulators were important mechanisms in tigecycline resistance in A. baumannii and identified several chromosomal hotspots that can be used for prediction of tIGecy Cline resistance.

TL;DR: Atl ubiquitous among staphylococcal species may substitute for the FnBPs ensuring low-level internalization via a mechanism that seems to share important features with the FnBP-mediated staphyllococcal uptake potentially being the prerequisite for the development of therapy-resistant chronic infections by staphlyococcal strains that lack FnB Ps.

TL;DR: Hypermutation is prevalent among clinical isolates of Achromobacter spp.

TL;DR: This newly developed liquid chromatography-tandem mass spectrometry (LC-MS/MS) method is a safe and rapid method for accurately identifying bacteria directly from positive blood culture flasks.

TL;DR: This study demonstrates that testosterone suppresses the initial infection of prostate epithelial cells by UPEC and reduces the survival of UPEC within IBCs after infection, and indicates a critical role for STAT3 in facilitating UPEC infection and persistence.

TL;DR: Rbf can specifically bind to the hla and psmα promoters to repress their expression, resulting in significantly decreased production of phenol-soluble modulins α (PSMα) and alpha-toxin, representing a type of acute infection by S. aureus.

TL;DR: The incorporation of β-Ala was a reasonable approach for new antimicrobial peptides design, and the new peptides Ano-1β and Ani-8β might be promising antimicrobial candidates in combating the increasing antibiotic-resistant bacteria.

TL;DR: The data suggest that Tp92 may play an important role in mediating endothelial cell activation by inducing the secretion of chemerin in activated endothelial cells.