D
Debarun Dutta
Researcher at Aston University
Publications - 62
Citations - 1311
Debarun Dutta is an academic researcher from Aston University. The author has contributed to research in topics: Contact lens & Medicine. The author has an hindex of 18, co-authored 51 publications receiving 879 citations. Previous affiliations of Debarun Dutta include Vision-Sciences, Inc. & Lloyd's Register.
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Action of Antimicrobial Peptides against Bacterial Biofilms
TL;DR: The major anti-biofilm mechanisms of antimicrobial peptides are: disruption or degradation of the membrane potential of biofilm embedded cells; interruption of bacterial cell signaling systems; and downregulation of genes responsible for biofilm formation and transportation of binding proteins.
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Factors influencing bacterial adhesion to contact lenses
TL;DR: A new bidentate phosphoramidite (N-Me-BIPAM) based on Shibasaki’s N-linked BINOL was synthesized and appears to be highly effective for rhodium-catalyzed asymmetric conjugated addition of arylboronic acids to α,β-unsaturated enones.
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Broad spectrum antimicrobial activity of melimine covalently bound to contact lenses.
TL;DR: Melimine may offer excellent potential for development as a broad spectrum antimicrobial coating for contact lenses, showing activity against all the bacterial and fungal ISO panel microorganisms, Acanthamoeba, and antibiotic resistant strains of P. aeruginosa and S. aureus.
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Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa.
TL;DR: Overall, melimine showed higher capacity for membrane disruption compared to Mel4, suggesting that the peptides permeabilized P. aeruginosa within 5 minutes, started lysis within 2 hours of exposure.
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Antimicrobial activity of four cationic peptides immobilised to poly-hydroxyethylmethacrylate.
TL;DR: The immobilisation of certain AMPs at nanomolar concentration to pHEMA is an effective option to develop a stable antimicrobial surface and shows any toxicity towards mouse L929 cells.