D
Debbie Tam
Researcher at University of Toronto
Publications - 4
Citations - 144
Debbie Tam is an academic researcher from University of Toronto. The author has contributed to research in topics: Internal medicine & Renal function. The author has an hindex of 3, co-authored 3 publications receiving 142 citations.
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Journal ArticleDOI
Segmental Intestinal Transporters and Metabolic Enzymes on Intestinal Drug Absorption
TL;DR: The influence of heterogeneity in absorptive, exsorptive, and metabolic functions on drug clearance, bioavailability, and metabolite formation after intravenous and oral dosing was examined and the intestinal clearance was found to be inversely related to the rate constant for absorption.
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Influence of p-glycoprotein, transfer clearances, and drug binding on intestinal metabolism in caco-2 cell monolayers or membrane preparations: a theoretical analysis
TL;DR: In this paper, the authors developed compartmental models to study the effects of intestinal secretion on the mean residence time (MRT) and rates of metabolism under first-order and nonlinear conditions.
Journal ArticleDOI
P-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrile
TL;DR: Results from composite data for the control and PCN-treated preparations were fit to published physiologically based pharmacokinetic models: the traditional model and the segregated flow model, and suboptimal parameters were obtained.
Journal ArticleDOI
Quantifying the benefits of remission duration in focal and segmental glomerulosclerosis
Arenn Jauhal,Heather N. Reich,Michelle Hladunewich,Moumita Barua,Bettina E. Hansen,David Naimark,Stéphan Troyanov,Daniel C. Cattran,Nicholl Ryan,P Ling,P. Lam,M. Romano,Shelley E. Albert,Ramona Aslahi,P. Aujla,Nancy Barrese,Mrinway Barua,Murray Berall,A N Berbece,D. Birbrager,Philip Boll,George Buldo,Carl J. Cardella,C Chan,PM Chan,Andre F. Charest,David Z.I. Cherney,Mala Chidambaram,Shirley Chow,Edward S. Cole,MM Cummings,Sandra Donnelly,A. Dunn,S Fong,Jason Fung,Jenette Goldstein,Ziv Harel,Gavril Hercz,S. Jassal,Sahar Kajbaf,Kamel S. Kamel,Amrit K. Kang,Stavros Karanicolas,Vincent Ki,S. Joseph Kim,D. Kim,Ana Konvalinka,Kiran K. Kundhal,Valerie Langlois,Poli Lekas,I Lenga,Christoph Licht,Jennifer Lipscombe,Charmaine E. Lok,John Ly,Myuri Manogaran,Rory F. McQuillan,Philip A. McFarlane,Harshul Mehta,David C. Mendelssohn,J. A. Miller,Gordon Nagai,Bharat Chotoo Nathoo,Gihad Nesrallah,M. Pandes,Sameer Pandeya,Rakesh Parekh,Rachel J. Pearl,York Pei,David L. Perkins,Jeffrey M. Perlman,Andreas Pierratos,Ramesh Prasad,Seetha Radhakrishnan,Meena Monmouth Junction Rao,Robert M. Richardson,Janet Roscoe,Amani Roushdi,Jitesh Sachdeva,Debbie Sapir,Joanna Sasal,Jeffery Schiff,James W. Scholey,Mary Ellis Schreiber,Xing Shan,Naheed Siddiqui,Tabo Sikaneta,S. Singh,Ritvik Singhal,Ajendra Sohal,Andrew W. Steele,Sumeet Suneja,Esther Szaky,Debbie Tam,Paul Tam,L. Teskey,Kathryn Tinckam,Robert H. King,S Tsui,Philip A. Turner,Davinder B. Wadehra,Jose Arturo Wadgymar,Ron Wald,Aziz Walele,Leonard C. Warner,Charlotte Wei,Jordan Weinstein,Cathryn Whiteside,Gina Wong,G. Wu,Teraiza Yassa,David Yuen,Jeffrey S. Zaltzman +112 more
TL;DR: In FSGS, unless remissions are maintained and relapses avoided, long-term renal survival remains poor and treatment strategies addressing remission duration should be an essential question in future trials.