R
Rommel G. Tirona
Researcher at University of Western Ontario
Publications - 100
Citations - 6500
Rommel G. Tirona is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Organic anion-transporting polypeptide & Organic anion transporter 1. The author has an hindex of 35, co-authored 94 publications receiving 5967 citations. Previous affiliations of Rommel G. Tirona include London Health Sciences Centre & Vanderbilt University Medical Center.
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Journal ArticleDOI
Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans.
TL;DR: The presence of multiple functionally relevant single-nucleotide polymorphisms (SNPs) in OATP-C in a population of African- and European-Americans is demonstrated and may represent a heretofore unrecognized factor influencing drug disposition.
Journal ArticleDOI
Drug and Bile Acid Transporters in Rosuvastatin Hepatic Uptake: Function, Expression, and Pharmacogenetics
Richard H. Ho,Rommel G. Tirona,Brenda F. Leake,Hartmut Glaeser,Wooin Lee,Christopher J. Lemke,Yi Wang,Richard B. Kim +7 more
TL;DR: Multiple transporters mediate the overall hepatic uptake of rosuvastatin, and NTCP may be a heretofore unrecognized transporter important to the disposition of roviastatin and possibly other drugs/statins in clinical use.
Journal ArticleDOI
The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
Rommel G. Tirona,Wooin Lee,Brenda F. Leake,Lu-Bin Lan,Cynthia Cline,Vishal Lamba,Fereshteh Parviz,Stephen A. Duncan,Yusuke Inoue,Frank J. Gonzalez,Erin G. Schuetz,Richard B. Kim +11 more
TL;DR: It is shown that the orphan nuclear receptor hepatocyte nuclear factor-4α (HNF4α; HNF4A) is critically involved in the PXR- and CAR-mediated transcriptional activation of CYP3A4, an important regulator of coordinate nuclear-receptor–mediated response to xenobiotics.
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Intestinal drug transporter expression and the impact of grapefruit juice in humans.
Hartmut Glaeser,Hartmut Glaeser,David G. Bailey,David G. Bailey,G K Dresser,J C Gregor,Ute I. Schwarz,Ute I. Schwarz,J S McGrath,E Jolicoeur,Wooin Lee,Brenda F. Leake,Rommel G. Tirona,Rommel G. Tirona,Rommel G. Tirona,Richard B. Kim,Richard B. Kim +16 more
TL;DR: OATP1A2 is likely the key intestinal uptake transporter for fexofenadine absorption whose inhibition results in the grapefruit juice effect, and an array of drug uptake and efflux transporters are expressed in the human intestine.
Journal ArticleDOI
Nuclear Receptors and the Regulation of Drug‐Metabolizing Enzymes and Drug Transporters: Implications for Interindividual Variability in Response to Drugs
TL;DR: There is compelling evidence to demonstrate that PXR, CAR, FXR, LXR, LDR, VDR, HNF4α, and AhR form a battery of nuclear receptors that regulate the expression of many important drug‐metabolizing enzyme and transporters.