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Deborah E. Britt
Researcher at Brown University
Publications - 11
Citations - 851
Deborah E. Britt is an academic researcher from Brown University. The author has contributed to research in topics: Synovial fluid & Chromosome 9. The author has an hindex of 8, co-authored 11 publications receiving 811 citations. Previous affiliations of Deborah E. Britt include Rhode Island Hospital.
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Journal ArticleDOI
Homology of lubricin and superficial zone protein (SZP): Products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25
TL;DR: It is hypothesized that CAP, a large joint arthropathy, may be associated with ineffective boundary lubrication provided by synovial fluid, and both SZP and lubricin occupy a new class of biomolecules termed tribonectins.
Journal Article
Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts.
TL;DR: Lubricin is secreted by synovial fibroblasts via expression of the MSF gene and is the only lubricating component in the final lubricating fraction of humansynovial fluid.
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Claudin expression in gastric adenocarcinomas: a tissue microarray study with prognostic correlation.
Murray B. Resnick,Mariuxi Gavilanez,Eric Newton,Tamako Konkin,Baishali Bhattacharya,Deborah E. Britt,Edmond Sabo,Steven F. Moss +7 more
TL;DR: Claudins 1, 3, and 4 and ZO-1 are strongly expressed in most gastric intestinal-type adenocarcinomas but less frequently in diffuse gastric cancers, which suggests their potential utility as diagnostic biomarkers and possible targets for therapeutic intervention.
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Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells.
Deborah E. Britt,Dong Fang Yang,Dong Qin Yang,Donna L. Flanagan,Helen Callanan,Yow Pin Lim,Sue Hwa Lin,Douglas C. Hixson +7 more
TL;DR: A novel protein LYsine-RIch CEACAM1 co-isolated (LYRIC) that is widely expressed and highly conserved between species is described, which suggests that LYRIC is recruited during the maturation of the tight junction complex.
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Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23.
Mats E. Gåfvels,Mandy Caird,Deborah E. Britt,Cynthia L. Jackson,David Patterson,Jerome F. Strauss +5 more
TL;DR: The results suggest that the putative VLDL/ApoE receptor could play a role in the uptake of triglyceride-rich lipoprotein particles by specific organs including striated and cardiac muscle and adipose tissue and in the transport of maternal lipids across the placenta.