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Deborah E. Shalev
Researcher at Hebrew University of Jerusalem
Publications - 41
Citations - 589
Deborah E. Shalev is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Peptide & Cyclic peptide. The author has an hindex of 15, co-authored 41 publications receiving 486 citations. Previous affiliations of Deborah E. Shalev include Jerusalem College of Engineering, Chennai & Azrieli College of Engineering Jerusalem.
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Journal ArticleDOI
Mass spectrometry reveals the chemistry of formaldehyde cross-linking in structured proteins.
Tamar Tayri-Wilk,Moriya Slavin,Joanna Zamel,Ayelet Blass,Shon Cohen,Alex Motzik,Xue Sun,Deborah E. Shalev,Oren Ram,Nir Kalisman +9 more
TL;DR: It is shown that cross-links in structured proteins are the product of two FA molecules and many of the cross- links could not be mapped onto known atomic structures, and thus provide new structural insights.
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Do food microemulsions and dietary mixed micelles interact
Shoshana Rozner,Deborah E. Shalev,Alexander I. Shames,Maria Francesca Ottaviani,Abraham Aserin,Nissim Garti +5 more
TL;DR: Results show that DMM and ME interact to create ME-DMM mixed micelles, providing a potential pathway for delivering solubilized molecules.
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The C-terminal domain of the HIV-1 Vif protein is natively unfolded in its unbound state
TL;DR: In this paper, the C-terminal domain of Vif (CTD, residues 141-192) mediates many of its interactions, and the solution structure in the unbound state using biophysical techniques and found that it is unstructured under physiological conditions.
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Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin.
Orit Weil‐Ktorza,Nischay K. Rege,Shifra Lansky,Deborah E. Shalev,Gil Shoham,Michael A. Weiss,Michael A. Weiss,Norman Metanis +7 more
TL;DR: 2D-NMR and X-ray crystallographic studies demonstrated a native-like three-dimensional structure in which the diselenide bridge was accommodated in the hydrophobic core without steric clash, thus solving a long-standing challenge in chemical insulin synthesis.
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Structural Basis for Inhibiting β-Amyloid Oligomerization by a Non-coded β-Breaker-Substituted Endomorphin Analogue
Anat Frydman-Marom,Marino Convertino,Riccardo Pellarin,Ayala Lampel,Ronit Shaltiel-Karyo,Daniel L. Segal,Amedeo Caflisch,Deborah E. Shalev,Ehud Gazit +8 more
TL;DR: It is suggested that hindering the self-assembly process by interfering with the aromatic core of amyloidogenic peptides may pave the way toward developing therapeutic agents to treat amyloids-associated diseases.