D
Deborah Hyland
Publications - 2
Citations - 199
Deborah Hyland is an academic researcher. The author has contributed to research in topics: In vivo & Ex vivo. The author has an hindex of 2, co-authored 2 publications receiving 118 citations.
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In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)
Julie M. Parmentier,Jeff Voss,Candace Graff,Annette Schwartz,Maria A. Argiriadi,Michael M. Friedman,Heidi S. Camp,Robert J. Padley,Jonathan S. George,Deborah Hyland,Matthew Rosebraugh,Neil Wishart,L. Olson,Andrew J. Long +13 more
TL;DR: The data presented here highlight the JAK1 selectivity of upadacitinib and supports its use as an effective therapy for the treatment of RA with the potential for an improved benefit:risk profile.
Journal ArticleDOI
Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors
Michael Friedman,Kristine E. Frank,Ana L. Aguirre,Maria A. Argiriadi,Heather Davis,Jeremy J. Edmunds,Dawn M. George,Jonathan George,Eric R. Goedken,Bryan A. Fiamengo,Deborah Hyland,Bin Li,Anwar Murtaza,Morytko Michael J,Gagandeep Somal,Kent D. Stewart,Edit Tarcsa,Stacy Van Epps,Jeffrey W. Voss,Lu Wang,Kevin R. Woller,Neil Wishart +21 more
TL;DR: Initial efforts to develop orally bioavailable analogs of 12 with improved selectivity of Jak1 over Jak2 are described.